A gel that combats the cause of vaginal dryness.

Blissel Vaginal Gel is an effective treatment for vaginal dryness. It treats the cause of vaginal dryness, helping your symptoms improve over time.
If you have vaginal dryness due to the menopause, we can help. Order Blissel Vaginal Gel online with us and we can deliver straight to you.
Blissel Vaginal Gel is a treatment for vaginal dryness that you insert into the vagina. It contains estriol, a type of oestrogen and steroid that occurs naturally in the body. It’s applied straight to your vagina, so it shouldn’t affect other aspects of your health.
Using Blissel Vaginal Gel helps your vagina make its natural lubrication again. This protects you from vaginal infections, atrophy and painful sex. Blissel is the only gel form of estriol currently available. You might find it easier to use than tablets, pessaries or creams.
After the menopause, your body stops producing as much of the female sex hormones as it used to. This can change how your vagina works. It can lead to the walls of your vagina becoming thinner, dryer and more easily irritated.
The estriol in Blissel Vaginal Gel works directly on the vagina, increasing the oestrogen levels in the area. It makes the tissues of your vagina work normally again and restores the microflora and pH balance. This keeps your vagina healthy and combats dryness.
Your dose will depend on your symptoms and general health. A clinician will help you figure out the right dose for you. You’ll often start using one 1g tube of Blissel Vaginal Gel a day, which contains 10mcg of estriol. After three weeks, your symptoms will usually have improved and you can lower the dose to one 1g tube twice a week.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
Your pack of Blissel Vaginal Gel should come with the required amount of disposable cannulas, one reusable white plunger and one tube of the gel. Only use Blissel Vaginal Gel as your clinician tells you to.
Blissel Vaginal Gel is absorbed rapidly. Peak plasma concentrations happen at around two hours after using. But it can take some time to see its full effects, as it needs time to change how the tissues of your vagina are working. Most people will see an improvement in the lubrication of their vagina within a few weeks, so they can switch to the maintenance dose. If you have been using Blissel Vaginal Gel for three weeks and you don’t feel it’s working, go back to your clinician or message us if you’re using our service.
If you use too much Blissel Vaginal Gel or even swallow it, there’s probably no need to worry. The dose of estriol in Blissel is very low so it’s unlikely to cause problems. There’s a chance you might feel some nausea or experience extra vaginal bleeding. If any of these symptoms worry you, contact your clinician.
If you forget to take Blissel, just apply it when you remember. If it’s less than 12 hours until your next dose, you can skip it and carry on with your treatment as normal. Don’t use more Blissel Vaginal Gel than you're prescribed to make up for missing a dose. If you keep forgetting your dose, try setting an alarm or using a reminder app to help you remember.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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Disclaimer: The information provided on this page is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please talk to a doctor.
The therapeutic effect of a new ultra low concentration estriol gel formulation (0.005% estriol vaginal gel) on symptoms and signs of postmenopausal vaginal atrophy. Menopause, 19(10), pp.1130-1139.
Blissel 50 micrograms/g vaginal gel. Patient Information Leaflet.
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