One-a-day tablet to keep you sweat free.

Lyrinel XL is a tablet that stops excess sweating at the source. So you can get your life back without cycling through deodorants.
When you order Lyrinel XL online with Treated, we deliver it straight to you. You can message our experts at any time for advice and we’ll check in with you to see how your treatment is going.
Lyrinel XL is a tablet that treats hyperhidrosis, a condition that causes excessive sweating. Hyperhidrosis can either affect only certain areas of the body or make you sweat all over. It might also change your skin health by changing the colour or texture, or even causing an infection. For some people, it can affect their confidence too. But no matter how severe your hyperhidrosis is, Lyrinel XL can help.
Lyrinel XL is an off-label treatment for hyperhidrosis. This basically means that even though it’s been proven to be a safe and effective treatment for the condition, it doesn’t actually have the specific licence to treat it. So it won’t usually be the first thing you try to stop your sweating. A clinician will probably recommend lifestyle changes (such as avoiding any triggers) and topical treatments like strong deodorants first.
The active ingredient in Lyrinel XL is oxybutynin. It’s also a delayed-release tablet, which means that small amounts of the drug are released throughout the day. So you don’t have to take it as often as the standard generic version, Oxybutynin.
Lyrinel XL is a type of drug called an anticholinergic. It works by stopping the acetylcholinesterase (ACh) enzyme from activating This has been shown to lower the amount you sweat.
Lyrinel XL comes in 5mg and 10mg dose tablets. The usual dose to start on is one 5mg tablet a day. If this doesn’t fully control your symptoms, talk to your clinician. They can help you figure out the right dose.
The maximum dose of Lyrinel XL is usually 10mg, but you shouldn’t need a dose this high for hyperhidrosis. Don’t raise your dose yourself, always talk to a clinician first. Increasing your dose slowly and with medical advice will help you avoid side effects, like dry mouth.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
Your clinician will tell you how exactly to take Lyrinel XL for hyperhidrosis. If you have any questions, read the leaflet that comes with your medication and ask if you’re still not sure.
The active ingredient in Lyrinel XL is quickly absorbed into the bloodstream, with its levels increasing for 4-6 hours in your body before being maintained over the next 24 hours. Its effects on sweat are rapid. So it starts reducing your sweat levels pretty quickly, but it also lasts.
Taking too much Lyrinel XL can cause side effects. If you take more than your normal dose, get medical attention. It’s helpful to bring the packaging of your medication with you when you seek help, so they can see how much you’ve taken.
You can try setting an alarm or using a reminder app to help you remember when it’s time to take your medication. If you miss a dose, skip that dose and take your next dose at the normal time. Don’t take more than you normally do to make up for missing some.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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Disclaimer: The information provided on this page is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please talk to a doctor.
Effect of local acetylcholinesterase inhibition on sweat rate in humans. Journal of Applied Physiology, 90(3), pp.757-762.
Lyrinel XL 10 mg prolonged release tablet - Summary of Product Characteristics (SmPC) - (emc).
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