Zyban
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Reviewed on Jan 22, 2025. by Mr Craig Marsh Independent Prescriber Registered with GPhC (No. 2070724) Next review due on January 22, 2028.
Mr Craig Marsh

Last updated on Jan 22, 2025.

Product info

  • Zyban is a prescription pill to help you quit smoking by reducing cravings.

  • It’s taken daily for 7-9 weeks.
  • It can increase your chances of quitting compared to going cold turkey

Price checker

150mg
£53.95
  • Prices include:
    Express shipping

    24 hour shipping by secure courier.

  • Consultation + Access to our clinicians

    Ask our experts anything you like, any time you want.

  • Total
    £53.95
    Save £0.00 each order
Zyban Buproprion

What is Zyban?

Zyban is a medication that was originally developed to treat depression, but it was soon found to be an effective stop smoking treatment.

Stopping smoking can be hard, and you need willpower to make it work. But Zyban has been proven more effective than just quitting cold turkey.

It’s a pill you take everyday, and then a couple of times a day. In just nine weeks, it helps you beat nicotine addiction to become stronger and healthier.

How Zyban works

It’s not fully understood how Zyban works, but it’s likely that it works on the part of the brain that is affected by addictive behaviour. By reducing the cravings associated with smoking, this can help make the process easier.

Using Zyban to quit smoking might not be suitable for everyone, but it can be of great benefit for many smokers who are struggling to quit.

How safe is Zyban?

Most people who use Zyban don’t experience significant side effects, but it’s important that you know what the risks are before starting treatment. You can find more info on these in the leaflet that comes with the medicine. But if you’re unsure or concerned about anything, just let us know, and we’ll answer any questions you have.

The most common severe symptom is fits, which occur in less than one in 1,000 of users. If you do experience a fit, stop taking Zyban and seek immediate medical help.

treated.com This page was written by The Treated Content Team.
Mr Craig Marsh 872
This page was medically reviewed by Mr Craig Marsh on January 22, 2025. Next review due on January 22, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Zyban Buproprion

How should I take Zyban?

Swallow the tablets whole, without halving or crushing them. Not swallowing them whole will mean the active ingredient will be released in one go, increasing the risk of side effects and making the treatment less effective. Zyban should not be taken shortly before you go to bed as it may cause insomnia, but it can be taken with or without food.

Taking Zyban and smoking

Instructions for Zyban will be included with the medication and you should follow them carefully to get the best out of the treatment. As Zyban is taken before you stop smoking, some forward planning is needed.

How to take Zyban

Week 1
Days 1-6: Take one tablet once a day
Day 7 – Take one tablet, twice a day, eight hours apart (not close to bedtime).

Week 2
Stop smoking this week and continue taking one tablet, twice a day.

Week 3 to 9
Continue taking one tablet, twice a day.
If you haven’t stopped smoking by week 7, your clinician will recommend stopping treatment.

If you’re over 65, you might have a lower dose or take one tablet a day for the duration of the course.

If you haven’t managed to stop smoking during this time, let us know. It may be that a different treatment could work better, or that you need a little extra support to help you quit.

What should I do if I miss a dose?

If you forget to take a dose, simply carry on with the next scheduled tablet. Do not take double the dose to make up for the missed dose as this will only increase the risk of side effects.

treated.com This page was written by The Treated Content Team.
Mr Craig Marsh 872
This page was medically reviewed by Mr Craig Marsh on January 22, 2025. Next review due on January 22, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Zyban Buproprion

Zyban isn’t suitable for everyone, and there are some things that you need to be aware of when taking it.

Here’s all the official info on it. If anything is unclear, let our clinician know, and they can talk with you about it.

Zyban Buproprion

FAQ: Zyban

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

What Zyban dosages are available and how do I use them?

Answer:
Zyban 150 mg are the only Zyban tablets available. Because it’s a slow-release tablet (tablets that release the active ingredient slowly), its levels can be maintained, offering steady support for stopping cravings.

If you’re over 65, have liver or kidney disease or if you’re more prone to seizures, you may need to take a lower dose of Zyban.

If I take too much Zyban, what should I do?

Answer:
If you take too much Zyban, seek immediate medical attention. An overdose of Zyban can lead to a greater risk of seizures, which can be dangerous.

It’s important to properly track what you have taken and when the next dose is due. You could try using a medication reminder app, to note down when you've taken your tablets. That can stop you from accidentally double-dosing.

What should I do if I want to stop taking Zyban?

Answer:
A course of Zyban usually lasts for between seven and nine weeks, and you might not see the effects right away. So if you stop taking it early, you won’t have the best shot at quitting smoking. If you feel like Zyban isn’t working for you, send us a message.

You may need to reduce the dosage slowly when you’re coming off Zyban. It’s important that you speak to our clinician about this in the first instance, so they can advise you on the safest way to do so.

Zyban or Champix: which is better?

Answer:
The two most commonly used prescription treatments for stopping smoking are Champix and Zyban. Although both essentially help reduce the cravings associated with quitting smoking, they work in different ways.

Zyban affects the part of the brain that’s related to addiction. Champix instead blocks how nicotine interacts with the receptors in the brain. It also releases dopamine, but to a lesser extent than Zyban. So they function differently, but provide similar results, at least in the long term. [1]

That’s not to say that they work the same for everyone. Finding the right treatment can vary from person to person, so there’s no one size fits all.

What’s the difference between Bupropion and Zyban?

Answer:
The active ingredient in Zyban is Bupropion, which is also the generic name for the treatment. In short, Bupropion and Zyban are the same medication, and they work in the same way.

There isn’t a generic version of Zyban available right now. So the branded form is the one to try if you want to quit smoking.

Can Zyban cause depression?

Answer:
As mood changes are a relatively common side effect of taking Zyban, it’s possible you may experience depression during the treatment. This usually goes away in a few weeks. But if you experience a significant change in mood, let our clinician know.

Is Zyban also helpful for weight loss?

Answer:
There is some evidence that Zyban can help in weight management, but it’s not precisely known why this happens. The effects are thought to be related to certain hormones in the body, [2] such as dopamine. In fact, bupropion is one of the active ingredients in the weight loss medication Mysimba.

We only offer Zyban as a stop smoking treatment. But it may be preferable for someone who also has concerns about putting on weight as a result of quitting.

Are there any over the counter stop smoking aids?

Answer:
Yes. There are many stop smoking aids that can be bought over the counter. Most of these products work by replacing the nicotine without all the other chemicals that are found in tobacco.
These include patches, gums, nasal sprays and lozenges.

There are also vape products (E-cigarettes) that deliver nicotine. Results from these NRT (nicotine replacement therapies) are positive, [3] but some find they just prolong the addiction.

Does Zyban work better than quitting cold turkey?

Answer:
Cold turkey means to stop smoking without slowly reducing the intake of the substance that you’re addicted to. In other words, to just stop smoking.

Some studies suggest that cold turkey is more effective than gradually cutting down [popover id=ref4]. But treatments like Zyban have been shown to be more effective than cold turkey alone, with some studies suggesting that it doubles your chances of quitting successfully [popover id=ref5].

Treated trusted sources:

  1. Ramazan Benli, A. Et al. 2017. A comparison of the efficacy of varenicline and bupropion and an evaluation of the effect of the medications in the context of the smoking cessation programme. Tobacco Induced Disease U.S.A.
  2. Gadde. K.M. Et al. 2012. Bupropion for Weight Loss: An Investigation of Efficacy and Tolerability in Overweight and Obese Women. Obesity Research. U.S.A. Wiley Online Library.
  3. Heydari, G. Et al. 2014. A comparative study on tobacco cessation methods: a quantitative systematic review. Pubmed. 2014. N.I.H. U.S.A. P.M.C.
  4. Cheong, Y. Et al. 2007. Does How You Quit Affect Success? A Comparison Between Abrupt and Gradual Methods Using Data from the International Tobacco Control Policy Evaluation Study. Nicotine and Tobacco Research. U.K. Oxford Academic.
  5. Roddy, E. (2004). Bupropion and other non-nicotine pharmacotherapies. BMJ, [online] 328(7438), pp.509–511

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Dr Daniel Atkinson

GP Clinical Lead
Dr-Daniel-Atkinson

Registered with GMC (No. 4624794)

Meet Daniel  

Ms Sanjeda Chowdhury

Superintendent Pharmacist + Independent Prescriber
Ms-Sanjeda

Registered with GPhC (No. 2202465)

Meet Sanjeda  

Mr Craig Marsh

Independent Prescriber
Mr-Craig

Registered with GPhC (No. 2070724)

Meet Craig  

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AI Overview

Many users report that Zyban is an effective aid for quitting smoking, successfully helping them stop. It is frequently noted for reducing the urge to smoke and lessening cravings, making the process easier. While a significant number of users experienced no side effects, a few found the product to be ineffective for them. Personal determination is still considered a key factor for success.

See all our reviews  

Read more about Zyban

Further reading

Take a look at our helpful health guides related to stop smoking.

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