Synjardy

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Reviewed on November 20, 2025. by Dr Alexandra Cristina Cowell Writer & Clinical Content Reviewer Registered with GPhC (No. 2241935) Next review due on Nov 20, 2028.

Last updated on November 20, 2025.

Product info

Synjardy combines empagliflozin and metformin to treat diabetes.
The dual-action treatment removes excess sugar and improves insulin sensitivity.
Synjardy is usually prescribed when metformin alone isn’t enough.

Price checker

Prices include:

Express shipping
24 hour shipping by secure courier.
Consultation + Access to our clinicians
Ask our experts anything you like, any time you want.
Total
£91.95

Save £0.00 each order

Synjardy: essential info
Synjardy: instructions
Important stuff you need to know
FAQ

What is Synjardy?

Synjardy is a dual action treatment used to lower your blood sugar when you have type-2 diabetes. Its two active ingredients, empagliflozin and metformin, have complementary methods of action to increase your insulin secretion as well as your cells’ insulin sensitivity.

Type-2 diabetes is a condition that you usually develop in adulthood as a result of a range of factors, such as your genetics and your lifestyle. It’s characterised by high concentrations of glucose in your bloodstream (hyperglycaemia) due to your pancreas not producing enough insulin, or your body not using the insulin it does produce correctly (which is called insulin resistance).

Diabetes can sometimes be controlled or avoided by making lifestyle adjustments or by just taking metformin on its own. Synjardy is typically only prescribed when metformin on its own (monotherapy) hasn’t worked to keep your blood sugar levels down.

How does Synjardy work?

Synjardy contains two active ingredients, both of which work in different ways to help lower your blood sugar.

Empagliflozin is what’s known as an SGLT-2 inhibitor. SGLT-2 inhibitors work by blocking the action of the SGLT-2 protein in your kidneys. This protein is responsible for preventing the glucose in your bloodstream from being passed into your urine. By blocking the action of this protein, more of the glucose in your bloodstream is excreted via urine, and so reduces your blood sugar levels.^[1]

Metformin is one of the most widely used treatments for diabetes, and it works in three ways to reduce your blood sugar: by making your cells more sensitive to insulin, stopping your liver from making glucose and delaying glucose absorption in your gut.^[2]^[3]

Like other type-2 diabetes treatments, Synjardy works best alongside a healthy diet and regular exercise.

What doses of Synjardy are there?

Synjardy is available in four different doses:

(empagliflozin/ metformin)

5 mg/850 mg
5 mg/1,000 mg
12.5 mg/850 mg
12.5 mg/1,000 mg

The dose that you’re prescribed will depend on your health needs, condition and any other treatments you’re already taking.

Treated trusted sources:

Zinman, B., et al. (2015b). Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. New England Journal of Medicine, 373(22), pp.2117–2128
NHS (2019). Metformin.
Horakova, O., et al. (2019). Metformin acutely lowers blood glucose levels by inhibition of intestinal glucose transport. Scientific Reports, 9

This page was written by The Treated Content Team.

This page was medically reviewed by Dr Alexandra Cristina Cowell on November 20, 2025. Next review due on November 20, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

FAQ: Synjardy

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

How is Synjardy different from other treatments for diabetes?

Answer:

Diabetes treatments come in a range of different forms, each with a different mode of action to lower your blood sugar. Metformin is usually the ‘first line’ treatment for type-2 diabetes, which can also be prescribed to you if you don’t yet have diabetes but are at risk of developing it. If metformin doesn’t work to control your blood sugar, or it’s not suitable for you, then you might be prescribed an additional or alternative type of treatment that will work in a different way.

Other types of treatment can include sulfonylureas, DPP-4 inhibitors and meglitinides, all of which work to increase your insulin secretion. The two active ingredients in Synjardy don’t affect your insulin levels, but instead lower your blood glucose levels in other ways.

Is Synjardy similar to any other treatments?

Answer:

Vokanamet and Xigduo are similar treatments to Synjardy, in that they both contain a combination of SGLT-2 inhibitor and metformin. But where Synjardy contains the SGLT-2 inhibitor, empagliflozin, Vokanamet contains canagliflozin and Xigduo contains dapagliflozin. This means that although all these treatments have a similar mode of action, you might find that one treatment works better for you.

Synjardy isn’t available as a generic medication. This means that the combination of active ingredients in it are unique to this treatment. You can get the individual components of Synjardy as separate tablets, but you might find it more convenient and cost-effective to take them as a combined tablet.

Which dose of Synjardy should I use?

Answer:

The dose of Synjardy that you’re prescribed might depend on any existing treatments that you’re taking and your overall health needs. So, for instance, you’ll likely be prescribed a low dose of Synjardy if you have certain kidney problems. Your clinician will recommend the best dose for you once you’ve talked to them about your health.

Do I need a prescription for Synjardy?

Answer:

Yes, you need a prescription for Synjardy. This is because it's not suitable for everyone, and your condition will need to be monitored whilst you’re taking it to make sure that it’s still safe and effective for you.