Synjardy is an oral antidiabetic treatment. It contains metformin and empagliflozin – two medicines with complimentary modes of action to lower your blood sugar.
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Synjardy is a dual action treatment used to lower your blood sugar when you have type-2 diabetes. Its two active ingredients, empagliflozin and metformin, have complementary methods of action to increase your insulin secretion as well as your cells’ insulin sensitivity.
Type-2 diabetes is a condition that you usually develop in adulthood as a result of a range of factors, such as your genetics and your lifestyle. It’s characterised by high concentrations of glucose in your bloodstream (hyperglycaemia) due to your pancreas not producing enough insulin, or your body not using the insulin it does produce correctly (which is called insulin resistance).
Diabetes can sometimes be controlled or avoided by making lifestyle adjustments or by just taking metformin on its own. Synjardy is typically only prescribed when metformin on its own (monotherapy) hasn’t worked to keep your blood sugar levels down.
How does Synjardy work?
Synjardy contains two active ingredients, both of which work in different ways to help lower your blood sugar.
Empagliflozin is what’s known as an SGLT-2 inhibitor. SGLT-2 inhibitors work by blocking the action of the SGLT-2 protein in your kidneys. This protein is responsible for preventing the glucose in your bloodstream from being passed into your urine. By blocking the action of this protein, more of the glucose in your bloodstream is excreted via urine, and so reduces your blood sugar levels.
Metformin is one of the most widely used treatments for diabetes, and it works in three ways to reduce your blood sugar: by making your cells more sensitive to insulin, stopping your liver from making glucose and delaying glucose absorption in your gut.
Like other type-2 diabetes treatments, Synjardy works best alongside a healthy diet and exercise.
What doses of Synjardy are there?
Synjardy is available in four different doses:
(empagliflozin/ metformin)
5 mg/850 mg
5 mg/1,000 mg
12.5 mg/850 mg
12.5 mg/1,000 mg
The dose that you’re prescribed will depend on your health needs, condition and any other treatments you’re already taking.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
SynjardyEmpagliflozin and Metformin
How to take Synjardy
You should always follow the advice of our clinician when taking Synjardy. To take it:
swallow the tablet whole with water
take it with food to lower the chance of you getting an upset stomach
take it twice a day
How long does it take Synjardy to work?
Synjardy should start to get to work to lower your blood sugar within a few days of taking it, but it can take a few weeks before you start to see any change in your HbA1c (the test of your average blood sugar levels over the last 2-3 months). If you don’t get many symptoms from your diabetes, it’s unlikely that you’ll feel much different from taking Synjardy, but that doesn’t mean that it’s not working to improve your health. It’s important that you continue your treatment to lower your risk of developing any long-term complications.
What should I do if I make a mistake when taking Synjardy?
If you accidentally take too much Synjardy and notice any adverse effects, you should seek medical help straight away. Taking too much Synjardy can lead to lactic acidosis, which can be very bad for your health. If you forget to take your dose of Synjardy, you should take it as soon as you remember. If you don’t remember until it’s time for your next dose, skip it and continue as normal - don’t double the dose to make up for the missed one.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
SynjardyEmpagliflozin and Metformin
SynjardyEmpagliflozin and Metformin
FAQ: Synjardy
Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.
How is Synjardy different from other treatments for diabetes?
Answer:
Diabetes treatments come in a range of different forms, each with a different mode of action to lower your blood sugar. Metformin is usually the ‘first line’ treatment for type-2 diabetes, which can also be prescribed to you if you don’t yet have diabetes but are at risk of developing it. If metformin doesn’t work to control your blood sugar, or it’s not suitable for you, then you might be prescribed an additional or alternative type of treatment that will work in a different way.
Other types of treatment can include sulfonylureas, DPP-4 inhibitors and meglitinides, all of which work to increase your insulin secretion. The two active ingredients in Synjardy don’t affect your insulin levels, but instead lower your blood glucose levels in other ways.
Is Synjardy similar to any other treatments?
Answer:
Vokanamet and Xigduo are similar treatments to Synjardy, in that they both contain a combination of SGLT-2 inhibitor and metformin. But where Synjardy contains the SGLT-2 inhibitor, empagliflozin, Vokanamet contains canagliflozin and Xigduo contains dapagliflozin. This means that although all these treatments have a similar mode of action, you might find that each treatment might be more or less suitable or effective for you.
Synjardy isn’t available as a generic treatment. This means that the combination of active ingredients in it are unique to this treatment, and there aren’t any other treatments that will work in quite the same way to lower your blood sugar. You can get the individual components of Synjardy as separate tablets, but you might find it more convenient and cost-effective to take them as a combined tablet.
Which dose of Synjardy should I use?
Answer:
The dose of Synjardy that you’re prescribed will depend on any existing treatments that you’re taking and your health needs. So, for instance, you’ll likely be prescribed a low dose of Synjardy if you have any kidney problems. Our clinician will recommend the best dose for you once you’ve talked to us about your health.
Do I need a prescription for Synjardy?
Answer:
Yes, you need a prescription for Synjardy. This is because it isn’t suitable for everyone, and your condition will need to be monitored whilst you’re taking it to make sure that it’s still safe and effective for you.
Why should I buy Synjardy online with Treated?
Answer:
Finding a diabetes treatment that works best for you can be tough, that’s why we provide tailored, expert aftercare when you get your treatment with us. Your medication will be sent to you promptly, securely and discreetly, and we’ll check in with you once you’ve started using it to see how you’re getting on.
If you’ve got any questions or concerns at any time, just log into your account and send one of our experts a message. We’ll take the stress out of your treatment, so you can prioritise your health.
Zinman, B., Wanner, C., Lachin, J.M., Fitchett, D., Bluhmki, E., Hantel, S., Mattheus, M., Devins, T., Johansen, O.E., Woerle, H.J., Broedl, U.C. and Inzucchi, S.E. (2015b).
Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. New England Journal of Medicine, [online] 373(22), pp.2117–2128. Available at:
Disclaimer: The information provided on this page is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please talk to a doctor.
