Colofac
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Reviewed on Jul 11, 2023. by Dr Alexandra Cristina Cowell Writer & Clinical Content Reviewer Next review due on July 12, 2026.
Dr Alexandra Cristina Cowell

Last updated on Jul 11, 2023.

Product info

  • Colofac is a medication used to relieve IBS symptoms.

  • It works by relaxing muscles in the intestines, reducing cramps and discomfort.
  • It can take up to an hour to work, with effects lasting for several hours.

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£35.95
  • Prices include:
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    24 hour shipping by secure courier.

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Colofac Mebeverine

What is Colofac?

Colofac is a medicine used to treat the symptoms of irritable bowel syndrome (or ‘IBS’ for short). It’s a common condition that affects your digestive system, causing symptoms like cramps, diarrhoea, constipation and discomfort. [2] Although IBS is a widespread condition, there’s no cure. However, changing your diet and using medication can help to improve your symptoms.

Colofac contains the active ingredient mebeverine hydrochloride, which is a type of antispasmodic. IBS is usually associated with pain, discomfort and spasms in the digestive system. Colofac works by relieving these spasms and other symptoms, allowing you to feel more comfortable.

How does Colofac work?

IBS is a condition that affects your lower gastrointestinal tract, including the small and large intestines. When your intestines spasm (squeeze or tighten), it can cause pain in your lower abdomen. Colofac’s active ingredient, mebeverine hydrochloride, is an antispasmodic. This means it relaxes the muscles in your intestines, which stops spasms from occurring. [1]

What doses of Colofac are there?

Colofac comes in 2 different doses: Colofac 135mg tablets and Colofac 200mg Modified-Release capsules.

Both contain the same active ingredient, mebeverine hydrochloride, but the 200mg version is a slow-release tablet. A slow-release tablet releases the drug gradually over a period of time rather than in one go.

Treated trusted sources:

  1. Daniluk, Jaroslaw & Malecka-Wojciesko, Ewa & Radomańska, Barbara & Rydzewska, Grazyna. (2022). The Efficacy of Mebeverine in the Treatment of Irritable Bowel Syndrome—A Systematic Review. Journal of Clinical Medicine. 11. 1044. 10.3390/jcm11041044.
  2. Patel N, Shackelford K. Irritable Bowel Syndrome. [Updated 2022 Oct 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK534810/
treated.com This page was written by The Treated Content Team.
Dr Alexandra Cristina Cowell 1218322
This page was medically reviewed by Dr Alexandra Cristina Cowell on July 12, 2023. Next review due on July 12, 2026.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Colofac Mebeverine

How to take Colofac

Both Colofac 200mg MR capsules and Colofac 135mg tablets should be taken 20 minutes before eating a meal, with a whole glass of water. Do not chew the tablets.

  • The dosage depends on the version of Colofac taken.
  • The starting dose for Colofac 200mg MR capsules is 1 capsule taken twice a day.
  • For Colofac 135mg tablets, 1 tablet is taken 3 times a day. This number can be lowered if symptoms improve, but do not take more than 3 tablets daily.

If you’re taking two tablets a day, take one before breakfast and the other before your evening meal. And for 3 times a day, take one before your breakfast, lunch and evening meal. Children under the age of 10 shouldn’t take Colofac, unless advised. [1]

How long does Colofac take to work?

Colofac usually starts to work around 1 hour after taking it.

Once you feel better, you can stop taking Colofac (but it’s better to ask our clinicians first before stopping). If your symptoms remain the same after 2 weeks have passed, contact our clinician for the next steps. [1]

Making a mistake whilst taking Colofac

If you forget to take a dose, take it when you remember. If it’s nearly time for your next dose, skip the missed dose. Do not take a double dose.

If you have taken more Colofac than required, talk to our clinicians or go to the A&E if you feel any side effects.

Treated trusted sources:

  1. National Health Service (2023). Mebeverine.
treated.com This page was written by The Treated Content Team.
Dr Alexandra Cristina Cowell 1218322
This page was medically reviewed by Dr Alexandra Cristina Cowell on July 12, 2023. Next review due on July 12, 2026.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Colofac Mebeverine

Colofac is not suitable for everyone. To make sure it’s safe for you there are some things you need to know.

Here’s all the official info on them. If anything is unclear, let our clinician know, and they can talk with you about it.

Colofac 135mg tablets | Colofac 200mg MR capsules

Colofac Mebeverine

FAQ: Colofac

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

What are the side effects of Colofac?

Answer:
Most people will not get any side effects. However, some may experience an allergic reaction. If this happens, go to your nearest A&E. 

This may include:

  • Difficulty in breathing

  • Swelling of the face, neck and throat

How does Colofac compare to other treatments?

Answer:
Buscopan is another medicine used to treat the symptoms of IBS. Buscopan contains the active ingredient, hyoscine butylbromide, which is another antispasmodic like Colofac. The difference between Colofac and Buscopan is that Colofac relaxes the muscles in your intestines, while Buscopan relaxes the muscles in your stomach, gut and bladder. This helps relieve symptoms such as stomach cramps. Buscopan also takes just 15 minutes to work, whereas Colofac takes a bit longer (around an hour). [1] Both treatments relieve IBS symptoms, but depending on your symptoms and what you prefer, our clinicians will recommend what’s best for you.

How effective is Colofac?

Answer:
Colofac is effective at easing the symptoms of IBS, but it’s not a long-term cure. That’s why it’s recommended that you change your diet and find triggers that make your condition worse. Exercise has also been shown to be healthy for your digestive system, along with controlling your stress levels.

Can I take Colofac whilst pregnant or breastfeeding?

Answer:
No. Colofac is not recommended to take during pregnancy or breastfeeding.

Treated trusted sources:

  1. National Health Service (2023). Buscopan.

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