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Reviewed on Sep 11, 2023. byDr Alexandra Cristina CowellWriter & Clinical Content ReviewerNext review due on September 12, 2026.
Last updated on Sep 11, 2023.
Product info
Paludrine/Avloclor is an anti-malarial travel pack that contains two different tablets.
It can prevent and protect you from developing malaria in high-risk countries.
The tablets are started a week before your travels and continued throughout.
The Paludrine/Avloclor Anti-malarial Travel Pack contains two different tablets to help prevent malaria before and after you travel to a malaria-risk country. It uses two active ingredients: proguanil hydrochloride and chloroquine phosphate. These medicines belong to a group called antimalarials.
Antimalarials are used in certain countries where there’s a high risk of malaria. Malaria is spread through bites from infected mosquitoes that carry a parasite into your blood. You should tell your prescriber what country you are travelling to to make sure the Anti-malarial Travel Pack is right for you.
While taking this medicine, you should also follow these recommendations to protect yourself from mosquitoes as much as possible:
use insect repellent on exposed skin;
wear light-coloured clothing, especially after sunset, as this is when mosquitoes are most active;
sleep under a mosquito net;
use insecticide spray and close doors and windows (if they’re not screened already).[1]
How does Paludrine/Avloclor work?
Paludrine/Avloclor contains two active ingredients for maximum protection against malaria. One of the tablets, Paludrine, contains a medicine called proguanil. Proguanil works by stopping the parasite from growing and reproducing. It does this by binding to an enzyme in the parasite that’s involved in its reproduction. It’s highly effective against one type of malaria parasite.
Avloclor (the other tablet in the travel pack) contains the other active ingredient, chloroquine. Chloroquine alters the DNA of the parasite, and binds to a molecule that causes the outer layer of the parasite to break down. This stops the parasite from growing in your red blood cells. And if you’ve already contracted malaria, it can help stop the parasite from multiplying. Chloroquine is especially effective at targeting malaria infections in the red blood cells without harming the rest of your body.[2]
Who is Paludrine/Avloclor for?
Paludrine/Avloclor is recommended for people travelling to countries where malaria is common, but you should check with your prescriber first.This is because some malaria parasites in certain countries have grown immune to certain anti-malarial medications.
Paludrine/Avloclor can also be used for people living in at-risk areas who aren’t immune to malaria. Usually, this will be in combination with another antimalarial treatment.[1]
What doses does Paludrine/Avloclor come in?
Paludrine/Avloclor comes in one dose for each of the active ingredients it uses. Paludrine contains 100 mg of proguanil hydrochloride, and Avloclor contains 250 mg of chloroquine phosphate. You’ll take each tablet at different times according to your prescriber’s instructions. The blister pack will have the days of the week on it and details on when to take it to help you remember.
This page was written by The Treated Content Team.
This page was medically reviewed by Dr Alexandra Cristina Cowell on September 12, 2023. Next review due on September 12, 2026.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
Follow the instructions given by your clinician carefully to ensure your anti-malarial medication works effectively.
Start taking Paludrine/Avloclor one week before you travel (or two days before if you’ve been prescribed it last minute).
Continue to take it throughout your stay.
Keep taking it for four weeks after leaving the at-risk area.
Take two Avloclor tablets once a week, on the same day each week.
Take two Paludrine tablets every day, at the same time each day.
You can take the tablets after you’ve eaten.
Swallow them whole with water.
Avoid giving this Anti-malarial Travel Pack to children under 1 year old. If your child is over 1 year of age, the appropriate dose varies by their age. Please ask your clinician for instructions on how to use it in children.
How long does Paludrine/Avloclor take to work?
Paludrine reaches its peak plasma concentration level at three to four hours, whereas Avloclor can reach its highest levels in one to six hours. Even after one dose, the medicines can be detected in your blood for more than four weeks.[1] Even after you’ve returned from your travels, it’s important to continue taking the medications to minimise the risk of malaria and ensure that there are no parasites in your blood.
What happens if I make a mistake using Paludrine/Avloclor?
If you accidentally take more Paludrine or Avloclor tablets than you should, seek urgent medical attention immediately (and bring the blister pack with you).
If you forget to take your Paludrine tablets, take them as soon as you remember. But if it’s close to the time of your next dose, skip the missed dose and wait till the next one. Don’t take a double dose to make up for a forgotten one.
If you forget to take your Avloclor tablets, take them as soon as you remember, then wait exactly seven days before your next dose. Stick to this new day of the week to continue your treatment course.
This page was written by The Treated Content Team.
This page was medically reviewed by Dr Alexandra Cristina Cowell on September 12, 2023. Next review due on September 12, 2026.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.
Will I get side effects while taking Paludrine/Avloclor?
Answer:
Like all medicines, Paludrine/Avloclor can cause side effects, but not everyone will get them. Tell your clinician if you’re taking any other medications before you start using Paludrine/Avloclor. Tell your prescriber if you’re experiencing any side effects whilst taking this medication, as you may need to stop and switch to a different anti-malarial medication.
In what countries can I take Paludrine/Avloclor?
Answer:
Paludrine/Avloclor will work in most malaria-risk countries, but tell your prescriber which specific country you are travelling to so they can best advise which anti-malarial you need. You can also check the CDC and NHS Fit for Travel websites to search for the country you are travelling to and see if there is any drug resistance in that country.
What are the alternatives to Paludrine/Avloclor?
Answer:
Paludrine/Avloclor (Anti-Malarial Travel Pack) is a branded treatment. You can, however, get a generic version of it (Chloroquine and Proguanil Anti-Malarial Tablets) from Boots. They work the same as they contain the same active ingredients, but there might be a difference in pricing, packaging, and appearance of the tablets. Typically, generic versions may be slightly cheaper.
Atovaquone/Proguanil is a different antimalarial treatment, which uses one of the same active ingredients, proguanil. But where Paludrine/Avloclor needs to be taken for a further four weeks after travel, you only need to take Atovaquone/Proguanil for one week after you’ve returned. It’s also available in branded versions: Malarone and Maloff Protect.
Another treatment for malaria prevention is Lariam, which uses the medicine mefloquine (also available in generic form). It’s only necessary to take it once a week, and you should also take it before and after your travels.
How effective is Paludrine/Avloclor?
Answer:
The active ingredients in Paludrine/Avloclor are widely used in the preventive treatment of malaria. Chloroquine combined with proguanil has been studied extensively to prove it’s both safe and effective. In one study, comparing it to a combination of atovaquone and proguanil, they found that both treatments were similarly tolerated.[1] Each active ingredient has also been found to have a successful cure rate of 90–100%.[2][3]
Do I need a prescription for Paludrine/Avloclor?
Answer:
Yes. With all anti-malarial treatments, you will need a prescription before you can start using them. Our clinicians will need to check what country you’re visiting and how long you’ll be there for before they can tell you how to use it properly.
Treated trusted sources:
Høgh, B et al. “Atovaquone-proguanil versus chloroquine-proguanil for malaria prophylaxis in non-immune travellers: a randomised, double-blind study. Malarone International Study Team.” Lancet (London, England) vol. 356,9245 (2000): 1888-94. doi:10.1016/s0140-6736(00)03260-8
Our experts continually monitor new findings in health and medicine, and we update our articles when new info becomes available.
Sep 11, 2023
Published by: The Treated Content Team.Medically reviewed by: Dr Alexandra Cristina Cowell, Writer & Clinical Content Reviewer
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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