Compare all weight loss treatments

Active ingredient
Available doses
Form
Lasts for
Made/marketed by
Pharmacy status
Prices starting at
Works in

Pemvidutide

Pemvidutide

GLP-1 and glucagon receptor agonist you inject weekly. A range of doses available to reduce your weight gradually.

See treatment  
-
-
-
-
-
-
-
-
Mounjaro

Mounjaro

Tirzepatide

Similar to Wegovy. Effective weekly weight loss injection that helps suppress your appetite.

See treatment  
-
-
-
-
-
-
-
-
Zepbound

Zepbound

Tirzepatide

A weekly injection that works in two ways to help you lose weight.

See treatment  
-
-
-
-
-
-
-
-
Wegovy

Wegovy

Semaglutide

Weekly injection for weight loss that works by regulating your appetite.

See treatment  
Semaglutide
0.25 mg, 0.5 mg, 1 mg, 1.7 mg, 2.4mg
Injection
Novo Nordisk
Prescription
£199.95
4 weeks
Xenical

Xenical

Orlistat

Branded version of Orlistat. It can help reduce how much fat is absorbed by the body.

See treatment  
Orlistat
120mg
Tablet
Neon Healthcare
Prescription
£61.95
1-3 months
Saxenda

Saxenda

Liraglutide

Highly effective daily injection. It interacts with your brain to make you feel more full.

See treatment  
Liraglutide
6 mg/ml
Injection
Novo Nordisk
Prescription
£86.95
2-3 weeks
Orlistat

Orlistat

Orlistat

Just like Xenical but without the branding. Can reduce fat absorption by up to 33%.

See treatment  
Orlistat
120mg
Tablet
Multiple
Prescription
£61.95
1-3 months
Mysimba

Mysimba

Buproprion + Naltrexone

A clinically proven weight loss pill. It works on receptors in the brain that control appetite.

See treatment  
Naltrexone/Bupropion
8 mg/90 mg
Tablet
Orexigen
Prescription
£143.95
8 weeks
Alli

Alli

Orlistat

A low dose version of Xenical. It reduces the amount of fat being absorbed by your body.

See treatment  
Orlistat
60mg
Tablet
GlaxoSmithKline
Pharmacy
£56.95
3-6 months
  • Manufacturers subject to change.
  • Start and duration of effects are estimations.
  • For more detailed information on your medication, read the patient information leaflet.

Is weight loss treatment right for me?

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How to choose a weight loss treatment

How much we weigh can impact various aspects of our lives. It can hold us back from taking part in certain activities, make us feel unhappy or even impact our mental health. That’s why taking the decision to lose weight is a pretty big one.

Weight loss treatments can be used as part of a healthy weight loss course. However, there are several to choose from and reading up on them may feel overwhelming, especially when you’re looking for weight loss treatments that actually work.

We’re here to help you get a better understanding of the weight loss medication options available, so you can make the best decision for you.

How do weight loss treatments work?

Weight loss treatments such as Xenical, Orlistat, and Alli work by effectively creating a barrier that stops fat from being absorbed into your intestines; this fat is passed naturally, which encourages weight loss in the process.

The active ingredients in Mysimba work differently and instead act on the brain. Bupropion works to reduce your appetite and Naltrexone helps to curb food cravings so that you don’t feel the urge to eat as often.

What do diet pills do?

When diet pills are used as part of a healthy diet and exercise programme they can have a positive effect on weight loss. However, it’s not just a case of popping a pill and carrying on regardless, the user will also have to follow a diet plan to help them achieve the best results with the least amount of side effects.

When you decide to embark on a weight loss journey supported by weight loss pills your clinician will outline details of a calorie-controlled diet and a regular exercise plan. Following these instructions will help you achieve your weight loss goals. It’s recommended you speak to your physician before taking part in a high-intensity exercise programme.

Do weight loss treatments work?

Licensed medicines like Mysimba and Orlistat have shown to be effective in aiding weight loss, as long as they’re used alongside a calorie controlled diet and exercise. However, how effective different weight loss medications are isn’t always directly comparable, because efficacy isn’t always measured in the same way.

Looking at the data available:

  • Clinical data for Alli found that an average of 46.7 percent of participants lost more than five percent of their weight, compared to 26.4 percent on the placebo, when taking it for six months.
  • For Orlistat, 37 percent of study participants lost at least five percent of their body weight, compared with 19 percent of those taking the placebo, when taking it for 12 weeks.
  • For Mysimba, 31 percent of participants observed a weight loss of five percent or greater, compared to the placebo group at 12 percent, when taking it for 56 weeks.
  • For Saxenda, 63.5 percent of study participants lost at least five percent of their body weight, compared to 26.6 percent in the placebo group, when taking it for 56 weeks.

Efficacy rates are a factor in what treatment you use, but they don’t necessarily decide which is best for you. One particular medicine might be better for you based on how much weight you aim to lose, or your medical history. So it’s always worth getting professional advice.

There is no magical weight loss treatment that works overnight, however, if you follow the advice offered by your prescriber, and are determined to stick to your diet and exercise plan, then there are treatments that work. There are some BMI boundaries that must be adhered to and, as previously mentioned, not all diet pills will work for everyone, but there are slimming pills that work in partnership with a diet and exercise programme to help you lose weight.

Xenical (Orlistat) - pros and cons

Clinical trials have found that following 56 weeks of treatment participants using orlistat were found to have an eight percent weight loss, versus four percent in the placebo group. However, the clinical trials also revealed that some people experience unpleasant side effects, such as fatty stools or flatulence. As Xenical is taken orally it may be favoured by users who aren’t keen on regular injections, like those used by Saxenda and Victoza which have to be regularly injected and first demonstrated by a medical professional.

Alli - pros and cons

One of the advantages of Alli is that it is available without prescription, you will still need to speak to a pharmacist before they can provide you with the treatment, but the simpler access can be viewed as a benefit to some people. Clinical trials have proven that Alli is only marginally effective in comparison to various other weight loss treatments as it is given at a lower dose. Both Xenical and Orlistat are administered in larger doses and so are often more effective at reducing weight. Alli might be more suitable for those who wish to lose a smaller amount of weight. Clinical trials have also revealed that taking Alli can result in uncomfortable side effects such as uncontrollable bowel movements, oily discharge, and gas from the anus.

Saxenda - pros and cons

The active ingredient in Saxenda, liraglutide, helped trial participants consistently lose at least five to 10 percent of weight when compared to placebo. It also regulates your hunger and fullness, and stabilises your blood sugar. This can make you feel less cravings and give you better control over your eating habits. However, Saxenda is a prescription injection treatment that requires an initial demonstration by a healthcare professional. Regular injections may be off-putting to some patients. The most common side effects included nausea, diarrhoea, and vomiting.

Litramine/XLS-Medical - pros and cons

Litramine is perhaps viewed as a more gentle weight loss treatment as it can be ingested via tea, sachet, or tablet. Side effects from Litramine are mild if they occur at all. Litramine attaches itself to fat in the body and stops the fat being absorbed by the intestines. Clinical trials found it to absorb as much as 27% of dietary fats. Available without prescription.

Mounjaro - pros and cons

Mounjaro is a weekly weight loss injection that was originally intended to be a diabetes treatment. In the UK, it can be used for weight loss if your BMI is over 30, or if it’s over 27 and you have a weight-related condition like diabetes.

It's a pen treatment that comes pre-filled. It contains tirzepatide, a GLP-1 agonist. GLP-1 is a hormone made by your body, which plays a role in controlling your appetite. GLP-1 agonists work by mimicking the effects of this hormone, and help you feel full.

Like other weight loss treatments, the pens are used alongside regular exercise and healthy eating. In trials that compared Mounjaro with a placebo, it was shown to help between 89-91% of patients lose more than 5% of their weight.

Mounjaro can sometimes cause nausea, which might put some people off using it. The side effects should usually settle as you get used to using it, though.

Wegovy - pros and cons

Wegovy also boasts the appeal of being a once weekly injection for weight loss. Although, the idea of self administering an injection can put some people off. The clinical trial results for Wegovy show that people lose more weight using semaglutide than when using liraglutide. Most side effects associated with Wegovy are gastrointestinal in nature, although headaches, tiredness and dizziness were also recorded. In most cases the side effects settled down quickly and didn’t stop patients from continuing with their treatment.

Mysimba - pros and cons

Mysimba will usually make you eat less food, which can cut out overeating habits and reduce your appetite. It’s also very effective. In a trial involving 1742 people, the Mysimba group lost 6.1% of their body fat, compared with 1.3% of the placebo group. There is, however, a higher risk of side effects than there is with some other weight loss treatments, and you’ll need a prescription for it before you can buy and take it.

Are there any weight loss treatments that work fast without exercise?

We’re afraid not. There are no magical solutions to losing weight. Weight loss medication can be used alongside a balanced diet and healthy exercise routine to help boost your weight loss goals. Adopting regular exercise into your routine should be viewed as an added positive, as it will help you with your weight loss journey but also provide other health benefits too. Exercise not only helps your physical health but your mental health too.

What is the best prescription weight loss treatment on the market?

The best prescription weight loss treatment for you is the one that fits with your lifestyle and your goals. Important aspects you need to take into consideration are side effects, administration and prescription. What is a good option for one person may be different to another person.

A medication that works and doesn’t cause uncomfortable side effects that allows you to enjoy a healthy lifestyle alongside it is a good prescription weight loss treatment.

What are the best over-the-counter weight loss treatments?

Alli and XLS are weight loss treatments that are available without prescription in the UK.

It’s always recommended you speak to a professional before commencing a weight loss programme of any kind or starting any medication, though, so you know which is the best option for you. 

Alli is a low dose version of Xenical, and can be taken if you’re over 18 and have a BMI above 28. XLS is a naturally- based weight loss tablet, has mild side effects, and can absorb as much as 27% of your dietary fat. Like most weight loss treatments, XLS is intended to be taken alongside a healthy diet and regular exercise.

How to safely use weight loss medication

Choosing to start a weight loss journey may seem daunting at first. Having all the information you need can make all the difference. Read more about weight loss medication and make sure you’re on the right path from start to finish so that you can safely achieve your goals.

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This page was medically reviewed by Ms Sanjeda Chowdhury, Superintendent Pharmacist on June 10, 2024. Next review due on June 10, 2026.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

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Treated

Here's how we're doing so far.

551
Ann

Reliable and efficient service, any queries are quickly answered .

551
Shafaqat

Absolutely outstanding service,,no complaints, have been less than impressed with other online prescription services,but treated are by far the best

551
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Fast service. Operators were flexible enough to accomodate my requirements. Happy with the results

551
Anonymous

Very easy to access, quick decision, sensitive handling of enquiries. Looking forward to working with them to improve my health

551
Sylvie

Thank you for your service

551
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No problems. Fast and efficient.

551
Niall

Product supplied is absolutely great, it has been beneficial to me and is definitely helping with my weight loss.

551
Anenna

Excellent service, thank you to the doctors always there to answer my questions. Quick service and deivery.

4.9

Our average rating based on 3204 reviews.

551
Enakpodia

I had an issue with my order not being delivered when I received an email saying it was delivered, I called the treated number and the kind person who spoke to me assured me he would look into the issue and possibly send me a new one. About a few days later, it arrived. So thankful for the prompt response. And I must say I love the packaging, very nice

551
Theresa

H I have missed my wegovy for 2 weeks . Got the new dosage of .5 .Do you think I should start from begigining again ?

551
Odafe Alvin

Amazing service. Changed my life.

251
James

Given to stop smoking however the cigarettes always come first and although I take the pills I am still unable to give up cigarettes

251
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A disaster but really my fault. Google maps has wrong closing time which is of an hour before I got there. And I was travelling for several days following, so I did not even stop by the shop because I knew there Invicorp woulkd have expired because there is no place to refrigerate it. Lesson learned. Thank you. Dani’s Stainton

551
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Great service.

551
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Service extremely good with appropriate questions asked before prescribing treatment.

551
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Excellent service, prompt delivery and Kliovance really helps with the menopause.

551
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Fantastsic

551
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I am very impressed and satisfied with the team. Prompt response and fast delivery.

451
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Shipping next day no arguments about that. Could do better when reordering as a mix up caused problems but sorted after return was made

551
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Always arrives on time and I’m kept informed of progress.

551
Paula P.

Excellent

451
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Arrived very quickly

551
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I have had it previously from my G.P so It worked as expected, extremely well. My problem is an accessing my G.P practice, they put ED well down their list of priorities. I found your service excellent, quick and efficient. I fully intend to continue using it

551
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Great service, prompt delivery.

551
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My experience with Treated has been nothing short of exceptional. Transitioning from the US to the UK, I needed to replenish my contraceptive pill supply, and Treated made the process incredibly smooth and hassle-free. The online consultation with a doctor was convenient and reassuring. I was able to explain my requirements, and the doctor provided me with several suitable alternatives, ultimately leading me to Eloine, which has been a perfect fit for me so far. The guidance and support I received throughout the process were invaluable, and it was evident that the doctor had my best interests at heart. What truly impressed me was the speed of the entire process. Once I made my decision and completed the necessary steps, my order was promptly dispatched and arrived at my doorstep the very next day. Such efficiency is a rarity these days, and I commend Treated for their commitment to customer satisfaction. As for the product itself, I have been using Eloine for just over a week now, and I am pleased to report that everything is going well. It's comforting to know that I have access to a reliable contraceptive option that meets my needs, all thanks to Treated. I am grateful for the peace of mind they have provided me, and I will certainly be returning for any future healthcare needs. Thank you, Treated, for exceeding my expectations.

551
Joanne N.

Easy to use, prescription dealt with quickly and medication arrived within a couple of days.

451
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Bsrorge

551
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Super

551
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Could not have been more responsive from order and review to delivery.

551
Kerry W.

Fast

451
Moobin M.

Great service

551
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All as requested. Very good service.

551
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Gives me a great peace of mind.

551
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Great

551
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Fast shipping

551
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shipping was not good,they kept on saying they came for delivery and couldn't find anyone I was there the whole time waiting for the delivery.

551
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Good service good reminders and ordering whilst still montering your health

551
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Fast and prompt as usual.

551
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Excellent shipping, never had a problem. Goods arrive on time.

551
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Great customer service. Reliable and honest. Highly recommend

551
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Fast delivery

451
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No problems experienced

551
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Amazing service from Treated! Highly recommend them 👍🏽

551
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5 star

451
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Delivery delayed but delivered on time at next attempt

551
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I've had no issues with ordering or receiving my prescription through post.

551
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Great service

551
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Quick and easy to use, medication delivered fast

551
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Very good

551
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Great easy quick service

551
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Excellent service, great support thank you

551
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Fast delivery and answers any questions promptly.

551
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551
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551
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Treats you like an adult and enables you to take your health concerns into your own hands

551
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551
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Brilliant

451
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V.g

551
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Prompt tha ks!

551
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551
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Reliable company

551
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The best site

351
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Ok but only average.

551
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Prompt service

551
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551
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Simple. Easy. Professional

551
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On time

551
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Good

551
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Pleased with the service, very straightforward to order and delivery was very fast.

551
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Everything was quick and professional

551
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Shipping is speedy and the product is amazing.

551
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551
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551
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551
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551
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551
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551
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551
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Fast efficient service

551
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5

551
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551
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551
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Simple online assessment and swift delivery

551
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551
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Fast delivery

551
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always efficient and prompt.

551
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Fast, Courteous service.

551
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The service was prompt. and my prescription arrived quickly

551
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great service, thank you

551
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551
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Arrived second day coz they used royal mail instead of DPD.

551
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All nice

551
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All good.

551
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Great service

551
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Express service

551
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551
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Well looked after me

551
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Took time to respond but was okay

551
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Great

551
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Efficient delivery

551
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Delivered on time, received timely notification.

551
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Good service

551
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Medications received on time.

551
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Service was spot on. So quick and helpful.

551
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A good service

551
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Excellent service thank-you

551
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Very quick and easy service. Also a helpful team. Thanks

551
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Perfect service

551
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Great fast convenient service!

551
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Good service. Company knows how to treat problems. Shipped when stated and delivered on time. Definitely use again.

551
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Great customer service and my treatment Kilofem is the best ever - no side effects and it makes me feel young again

551
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Arrived on time, well packaged.

451
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Order and subscription changes are a little cumbersome. However shipping and service are A1

551
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Brilliant service and very fast delivery!

551
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Pleased with ordering and the treatment

551
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Really helped me

551
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Trusted service and great service - next day delivery and I can rely on them to send regularly.

551
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Ordering was straight forward, tablets delivered promptly and well packaged, and instructions were clear, thanks.

551
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100% recomended.Great service

551
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Excellent service

451
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fine

551
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Excellent delivery. Can’t fault.

551
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Quick and efficient service, delivered discreetly the next day. Thank you.

551
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Effective

551
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Great service, no wait time

551
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Great

551
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Quick assessing for medicine suitability. Quick delivery and good communication throughout.

551
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Straightforward and quick service!

551
Claire B.

Good however communication could sometimes be better

251
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Delivered on time

451
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Thank you

551
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Easy and good procedure to get treatment

551
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Excellent product

551
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Excellent service!!! Ordered what I needed sent a picture of my prescription and the parcel arrived the next day!!! Will definitely order again and have recommended to others!!!

551
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Fast shipping

551
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Very quick service all round

551
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So quick and simple. Recommend

551
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Great

551
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Very convenient hassle free service.

551
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Easy to use good communication and fast shipping

551
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Great service

551
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Efficient no issues re delivery

551
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Fabulous service

551
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Brilliant service. Not a bad word to say!

551
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It was fast, professional and it's the right med for what I selected in there.

551
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This review requires content. Oh well..

551
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Great service, quite effortless.

551
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Top notch

551
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Brill service

551
Maryam N.

N/a

551
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Excellent service quick and easy to use

551
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Fast and exact order

551
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Superb service and quick delivery 10/10

551
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Excellent service

451
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Was ok

451
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Regular & on time

551
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Thank you for fast delivery

551
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Shipping is extremely quick and satisfiying

551
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Good stuff

551
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Good service

551
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Great fast delivery

551
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Very good service well packaged

551
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Speedy delivery great service

551
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The shipping was great n received on time

551
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Excellent service.

551
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Excellent service

551
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Had to rearrange my delivery DPD were excellent

551
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The service was excellent and the shipping came just as expected without any complications. I will be using the service!!!

551
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Great experience

551
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Answered my questions promptly and explained what I had to do

551
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Fast shipping. Great communication definitely recommend

551
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First class service, shipping and no awkward tin god gatekeeping like Pharmacy4U - who couldn’t find their arse with both hands!!

551
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Excellent

551
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Excellent

551
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Very quick and efficient

551
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Good service

551
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Easy and efficient

451
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Very good and efficient.

551
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Quick delivery and well packed , email to see how you are getting on . Cery pleased and highly recommend

551
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Great company, fast delivery

551
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Excellent advice and service

551
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The service is excellent.

451
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item arrived promptly and was well packaged! A+++

551
John S.

Good as always

551
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Very pleased with this company keeps in touch with speedy delivery. Brilliant...

551
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Good website, good Comms, swift delivery

551
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Delivered on time great service discrete and professional.

551
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Fast response

551
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Extremely helpful, med on time

551
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Great service

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