Mysimba
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8mg/90mg
£143.95
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Reviewed on Apr 16, 2025. by Dr Daniel Atkinson GP Clinical Lead Registered with GMC (No. 4624794) Next review due on April 16, 2028.
Dr Daniel Atkinson

Last updated on Apr 16, 2025.

Product info

  • Mysimba is a prescription tablet for people with a BMI of 27 or above.

  • It targets specific areas of the brain to control appetite.
  • To get the best from it, take it alongside a healthy diet and exercise plan.

Price checker

8mg/90mg
£143.95
  • Prices include:
    Express shipping

    24 hour shipping by secure courier.

  • Consultation + Access to our clinicians

    Ask our experts anything you like, any time you want.

  • Total
    £143.95
    Save £0.00 each order
Mysimba Buproprion + Naltrexone

What is Mysimba?

Mysimba is a weight loss tablet that works in the brain to alter feelings of hunger and how your body spends energy. You’ll start off on a low dose of one tablet per day, and gradually increase this to two tablets twice a day over the first four weeks.

Mysimba is a medicine that’s only available on prescription, so you’ll need to have a consultation with us about it before you use it.

How does Mysimba work?

Mysimba weight loss tablets contain naltrexone and bupropion, and these work on the specific area of the brain that controls how much food you eat and how energy is spent. By affecting cravings for food, it makes it less likely you’ll overeat, which can lead to significant weight loss if you make adjustments to your lifestyle too.

The ingredient bupropion is also used in some antidepressant medications, as well as a popular stop smoking treatment called Zyban. So Mysimba is quite different to the weight loss tablet Orlistat, which affects how much fat you take up from food.

Is Mysimba effective?

Mysimba has been shown to work well in clinical trials, and be even more effective when used alongside weight loss management counselling. In a study of people taking it over 56 weeks, there was an average weight loss of 5.4%, and an average weight loss of 8.1% in people who also had behavioural support.[1]

In a combined analysis of studies, up to 42% of people taking Mysimba over 56 weeks lost at least 5% of their body weight, and up to 22% lost 10% of their body weight.[2] So it has proven to be effective for a sizeable portion of people that take it.

Treated trusted sources:

  1.  www.medicines.org.uk. (2023). Mysimba 8 mg/90 mg prolonged-release tablets – Summary of Product Characteristics (SmPC) – (emc).
  2. European Medicines Agency. Mysbimba. (2015) EPAR summary for the public. Science Medicines Health.
treated.com This page was written by The Treated Content Team.
Dr Daniel Atkinson 312
This page was medically reviewed by Dr Daniel Atkinson on April 16, 2025. Next review due on April 16, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Mysimba Buproprion + Naltrexone

How to take Mysimba pills

Read the leaflet that comes with the medication before you take Mysimba. If there’s anything you aren’t sure about, let us know.

  • During week one of treatment, take one tablet once a day in the morning.
  • During week two, take one tablet twice a day, one in the morning and one in the evening
  • During week three, take two tablets in the morning and one in the evening.
  • From week four onwards, take two tablets in the morning and two in the evening.
  • Simply swallow the tablet whole with water, without crushing or breaking them.
  • It’s better to take them with or after a meal and not on an empty stomach.
  • You’ll normally have your weight monitored as the course progresses to make sure it’s working for you.

What should I do if I forget to take Mysimba?

If you forget your Mysimba dose, don’t worry – just take your next dose as normal and continue the course. Don’t take double the amount at your next dose, because this won’t have any benefit and increases the risk of side effects. If you’re having trouble remembering to take the medication, you might find it useful to set a daily reminder to take it at specific times, or take it with a specific meal each day.

What should I do if I take too much Mysimba?

If you’ve taken too much Mysimba, you should seek immediate medical attention. Go to your nearest hospital and take your Mysimba packaging with you if possible.

Taking the tablets at the same time each day can help you to remember when to take your dose and can prevent you from taking too much by accident.

treated.com This page was written by The Treated Content Team.
Dr Daniel Atkinson 312
This page was medically reviewed by Dr Daniel Atkinson on April 16, 2025. Next review due on April 16, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Mysimba Buproprion + Naltrexone

Mysimba isn’t suitable for everyone, and there are some things that you need to be aware of when taking it

Here’s all the official info on it. If anything is unclear, let our clinician know, and they can talk with you about it.

Mysimba Buproprion + Naltrexone

FAQ: Mysimba

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

How safe is Mysimba?

Answer:
Mysimba is a safe treatment for the majority of people that use it. In a safety and tolerability review of weight loss medications, the majority of side effects associated with naltrexone and bupropion were transient,[1] meaning they only lasted for a short amount of time.

But you should still read the leaflet that comes with Mysimba before you take it, and report anything unusual to a clinician.

Is there such a thing as generic Mysimba?

Answer:
There isn’t a non-branded version of Mysimba available currently, although the medication is known by different names overseas (in the USA, it’s called Contrave).

The active components in Mysimba are available in other medications. For example, Zyban, a stop smoking treatment, contains bupropion. But this isn’t suitable for use in weight loss.

Mysimba, Xenical or Saxenda: what’s the difference?

Answer:
Mysimba shares some similarities with other treatments for weight loss. It’s a tablet, like Xenical, but works in a different way to this medication. Xenical, instead, works by preventing the body from digesting fat, which is eliminated without being fully processed by the body.  

Like Saxenda, Mysimba has an effect on appetite, but the way the medication is administered is quite different (Saxenda is an injection).

So which is better? It depends on a number of things: what you’ve used before, whether it was successful, and to an extent how much weight you need to lose and how quickly you want to lose it. Our clinicians can discuss your weight loss goals with you before helping you settle on a treatment they think will work best for you.

Can I only get Mysimba on prescription?

Answer:
Yes, you’ll need a prescription to get Mysimba, whether you’re purchasing it online or directly from the pharmacy. This is because its use needs to be monitored by a clinician. For example, if you don’t lose 5% of your weight during the first 16 weeks of treatment, it’s likely you’ll need to try another medication or method of losing weight. Your blood pressure may need to be monitored as well.

Can you get side effects with Mysimba?

Answer:
Some people who use Mysimba may get side effects, as is the case with any medication. In some cases these might be mild or pass after a short time, but a minority of people may get more serious side effects.

If you do develop serious side effects, such as an allergic reaction, get urgent help right away at your nearest hospital.

Do I need to change my diet and exercise more when taking Mysimba?

Answer:
For any weight loss treatment to work at its best, you’ll need to eat a healthy balanced diet and get regular physical activity when taking it. If you don’t make lifestyle changes but do manage to lose weight with treatment, it’s possible that you’ll regain the weight you lost if you haven’t developed good habits to maintain a healthy weight.

The NHS website has a wealth of information about different ways to approach weight loss, including diet plans and exercise routines.[2]  If you’ve not exercised in a while or you’re new to doing it regularly, it might be helpful to start with some easy-going circuits to start off with. From there, you can build on your fitness and increase the amount of activity you do.

Are changes to my diet and exercising alternatives to Mysimba?

Answer:
Exercise and adjustments to your diet are methods that should be used alongside weight loss treatment, rather than as alternatives to it. In fact, without diet and exercise, it’s unlikely that the treatment will be successful. Our clinician will be able to advise you on the lifestyle changes that’ll be safe and effective for you.

Treated trusted sources:

  1. Patel, K. et al (2017). Taylor and Francis Online. Clinical Focus: Cardiovascular Disease – Review. Safety and tolerability of new-generation anti-obesity medications: a narrative review.
  2. NHS (2020). Lose weight – Better Health. nhs.uk.

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Dr Daniel Atkinson

GP Clinical Lead
Dr-Daniel-Atkinson

Registered with GMC (No. 4624794)

Meet Daniel  

Ms Sanjeda Chowdhury

Superintendent Pharmacist + Independent Prescriber
Ms-Sanjeda

Registered with GPhC (No. 2202465)

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Mr Craig Marsh

Independent Prescriber
Mr-Craig

Registered with GPhC (No. 2070724)

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Here’s what you had to say

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AI Overview

Users report mixed results. Many experience significant benefits, including weight loss and a noticeable reduction in appetite and cravings. However, a substantial number of users state the product had no effect or even caused weight gain. Common side effects include nausea, dizziness, headaches, and a feeling of restlessness. Less frequent but reported side effects are dry mouth, stomach discomfort, and skin rashes. Some users stopped treatment due to the severity of these adverse effects.

See all our reviews  

Read more about Mysimba

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