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Mysimba helps you to lose weight by working on the receptors of the brain that control appetite. Together with a healthy diet and exercise, it can help you lose weight.
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Mysimba is a weight loss tablet that works in the brain to alter feelings of hunger and how your body spends energy. You’ll start off on a low dose of one tablet per day, and gradually increase this to two tablets twice a day over the first four weeks.
When it’s used alongside a calorie controlled diet and regular exercise, it can be very effective at helping people lose weight. In clinical trials, people taking Mysimba had a ‘mean’ (average) weight loss of 5.4% when taking it over 54 weeks, and a mean weight loss of 8.1% when it was combined with behavioural counselling.
Mysimba is a medicine that’s only available on prescription, so you’ll need to have a consultation with us about it before you use it.
Mysimba weight loss tablets contain naltrexone and bupropion, and these work on the specific area of the brain that controls how much food you eat and how energy is spent. By affecting cravings for food, it makes it less likely you’ll overeat, which can lead to significant weight loss if you make adjustments to your lifestyle too.
The ingredient bupropion is also used in some antidepressant medications, as well as a popular stop smoking treatment called Zyban. So Mysimba is quite different to the weight loss tablet Orlistat, which affects how much fat you take up from food.
Mysimba has been shown to work well in clinical trials, and be even more effective when used alongside weight loss management counselling. In a study of people taking it over 56 weeks, there was an average weight loss of 5.4%, and an average weight loss of 8.1% in people who also had behavioural support.
In a combined analysis of studies, up to 42% of people taking Mysimba over 56 weeks lost at least 5% of their body weight, and up to 22% lost 10% of their body weight. So it has proven to be effective for a sizeable portion of people that take it.
European Medicines Agency. Mysbimba. EPAR summary for the public. Science Medicines Health. 2015.
Mysimba 8 mg/90 mg prolonged-release tablets - Summary of Product Characteristics (SmPC) - (emc). [Accessed 22 Mar. 2022].
Patel, K. et al. Taylor and Francis Online. Clinical Focus: Cardiovascular Disease - Review. Safety and tolerability of new-generation anti-obesity medications: a narrative review. 2017.
Read the leaflet that comes with the medication before you take Mysimba. If there’s anything you aren’t sure about, let us know.
If you forget your Mysimba dose, don’t worry – just take your next dose as normal and continue the course. Don’t take double the amount at your next dose, because this won’t have any benefit and increases the risk of side effects.
If you’re having trouble remembering to take the medication, you might find it useful to set a daily reminder to take it at specific times, or take it with a specific meal each day.
If you’ve taken too much Mysimba, you should seek immediate medical attention. Go to your nearest hospital and take your Mysimba packaging with you if possible.
Taking the tablets at the same time each day can help you to remember when to take your tablet and prevent you from taking too much by accident.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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