Komboglyze is a dual ingredient tablet treatment that works to lower the high blood sugar caused by type-2 diabetes.
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Komboglyze is a dual-action diabetes treatment. It contains a combination of saxagliptin, which is a DPP-4 inhibitor, and metformin, which belongs to a class of medicines called biguanides. It’s used to lower the high blood sugar caused by type-2 diabetes when monotherapies (one active ingredient on its own) such as metformin haven’t worked.
Type-2 diabetes is a condition that you normally get in adulthood as a result of your body not producing as much insulin as it should (a hormone that helps you to digest the sugar you eat) or not effectively using the insulin that it does produce. Sometimes it can be controlled by changing your diet and exercising more, but where this isn’t working to reduce your blood sugar levels, treatments are often recommended.
How does Komboglyze work?
Komboglyze works to lower your blood sugar levels by increasing the amount of insulin that your pancreas produces and lowering the amount of glucose that your body makes.
Metformin, one of Komboglyze’s two active ingredients, is often used as the first-line treatment of type-2 diabetes, and has been in use since the 1950s. It works by reducing the amount of sugar that’s made in your liver and increasing your cells’ sensitivity to insulin, which makes them better able to store the sugar that you eat and remove it from your blood.
Saxagliptin, like other DPP-4 inhibitors, blocks the breakdown of incretins - hormones that instigate insulin secretion when you eat. By extending the length of time that incretins are active in your system, saxagliptin increases the amount of insulin that gets secreted by your pancreas, which helps to lower your blood sugar levels.
What doses of Komboglyze are there?
Komboglyze is available in two doses. Both treatments contain 2.5mg of saxagliptin, but different amounts of metformin. The lower dose treatment contains 850mg of metformin, and the higher one contains 1,000mg of metformin. Our clinician will recommend the most suitable dose treatment for you based on your health needs.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
KomboglyzeSaxagliptin; Metformin
How to take Komboglyze
You should always take Komboglyze exactly as prescribed by our clinician. To take Komboglyze simply swallow one tablet, whole, with water. The recommended dose is one tablet twice a day. You might be prescribed a lower dose if you have kidney problems. It’s recommended that you take Komboglyze with a meal to reduce your risk of getting an upset stomach.
How long does it take Komboglyze to work?
Komboglyze should get to work quickly to increase your insulin levels and lower your glucose production, but it might take a few weeks for your blood sugar levels to go down. Your HbA1c (the test of your average blood glucose levels over the past 2-3 months) will be monitored whilst you’re taking it to check that it’s working properly. If your HbA1c doesn’t show the required improvement after a few months then you might need to try an alternative treatment.
What should I do if I make a mistake when taking Komboglyze?
You should seek medical help straight away if you take more than your recommended dose of Komboglyze. If you forget your dose, you can take it when you remember - so long as it’s not too close to your next scheduled dose. If it is, skip your forgotten dose and continue as normal. Don’t double the dosage to make up for the missed one.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
KomboglyzeSaxagliptin; Metformin
KomboglyzeSaxagliptin; Metformin
FAQ: Komboglyze
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How is Komboglyze different from other treatments for diabetes?
Answer:
Different diabetes treatments can come under different categories, each of which will have a different mode of action as to how it works to lower your blood sugar. Some of the most commonly prescribed types of diabetes treatments are:
Biguanides - metformin, the most commonly prescribed first-line treatment for type-2 diabetes, comes under this category
Sulfonylureas - these work by increasing the amount of insulin secreted by the pancreas. You might be prescribed a sulfonylurea instead of metformin if it isn’t suitable for you
DPP-4 inhibitors - these work by blocking the break-down of hormones which stimulate insulin secretion
GLP-1 agonists - these treatments are often injected, and they increase your levels of incretins - the hormones that help your pancreas produce more insulin
SGLT-2 inhibitors - these work by increasing the amount of glucose that gets excreted in your urine
Komboglyze contains two of these different types of treatments - metformin (a biguanide) and saxagliptin, which is a DPP-4 inhibitor. You can get different treatments which contain just one of these types of medicines (monotherapy) or different combinations of these types of medicines.
Is Komboglyze similar to any other treatments?
Answer:
You can get other combination treatments that include metformin and a DPP-4 inhibitor, which will have a similar mode of action, such as Eucreas or Janumet. The active ingredients that they use are slightly different, though, so you might find them to be more or less suitable for you based on how your body responds to it.
You can also get metformin or saxagliptin on their own under different brand names. Saxagliptin on its own is sold under the brand name Onglyza.
How effective is Komboglyze?
Answer:
Saxagliptin and metformin as a combination treatment has been proven in clinical studies to be more effective in reducing blood sugar levels than placebo. It was also shown to be effective for, and well-tolerated by, people whose blood sugar levels were inadequately controlled by metformin alone.
Do I need a prescription for Komboglyze?
Answer:
Yes, you need a prescription for Komboglyze. This is because it isn’t suitable for everyone, and your blood sugar levels will need to be monitored whilst you’re using it to make sure that it continues to be safe, suitable and effective for you.
Why should I buy Komboglyze online with Treated?
Answer:
Navigating the maze of diabetes treatments isn’t always easy, and finding a treatment that works for you and suits your lifestyle can be frustrating. That’s why our expert team offers proven treatments and tailored advice to help you choose the best option for you.
Your treatment will be sent straight to your door promptly and discreetly. And if you’ve got any questions or concerns at any time, all you need to do is log into your account and send one of our clinicians a message.
DeFronzo, R.A., Hissa, M.N., Garber, A.J., Luiz Gross, J., Yuyan Duan, R., Ravichandran, S. and Chen, R.S. (2009).
The Efficacy and Safety of Saxagliptin When Added to Metformin Therapy in Patients With Inadequately Controlled Type 2 Diabetes With Metformin Alone. Diabetes Care, [online] 32(9), pp.1649–1655. Available at:
Disclaimer: The information provided on this page is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please talk to a doctor.
