Mebeverine
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Reviewed on Sep 03, 2023. by Dr Daniel Atkinson GP Clinical Lead Registered with GMC (No. 4624794) Next review due on September 04, 2026.
Dr Daniel Atkinson

Last updated on Sep 03, 2023.

Product info

  • Mebeverine is an antispasmodic medication used to relieve symptoms of IBS.

  • It works by relaxing the muscles in the intestines, reducing cramps and discomfort.
  • It may take up to an hour to work, with effects lasting several hours.

Price checker

£37.95
  • Prices include:
    Express shipping

    24 hour shipping by secure courier.

  • Consultation + Access to our clinicians

    Ask our experts anything you like, any time you want.

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Mebeverine Mebeverine

What is Mebeverine?

Mebeverine treats symptoms of irritable bowel syndrome (IBS). It’s an antispasmodic, meaning it suppresses bowel spasms, preventing frequent bowel movements. IBS is a condition affecting the gastrointestinal tract. It causes symptoms like cramps, abdominal pain and abnormal bowel movements.[1]
There’s no cure for IBS, but treatments work to ease symptoms associated with it.

How does Mebeverine work?

Mebeverine mainly functions as an antispasmodic by targeting the smooth muscles of the gastrointestinal tract. This relaxes the muscles, preventing spasms from occurring in the lower abdomen and gut, which helps relieve discomfort associated with IBS. [2]It also has a local anaesthetic effect, which can reduce the sensitivity and pain in the gut. [3]

What versions of Mebeverine are there?

There are two versions of mebeverine:

1) Mebeverine hydrochloride 135mg film-coated tablets
2) Mebeverine 200mg modified-release capsules

The difference between the two is that the modified-release capsules gradually release the active ingredient throughout a longer period of time, rather than in one go. This allows you to have the effects lasting all day with fewer pills.

Treated trusted sources:

  1. Patel N, Shackelford K. Irritable Bowel Syndrome. [Updated 2022 Oct 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-.
  2. Daniluk, J., Malecka-Wojciesko, E., Skrzydlo-Radomanska, B., & Rydzewska, G. (2022). The Efficacy of Mebeverine in the Treatment of Irritable Bowel Syndrome—A Systematic Review. Journal of Clinical Medicine, 11(4).
  3. Mebeverine Leaflet. EMC. Accessed: 25 August 2023
treated.com This page was written by The Treated Content Team.
Dr Daniel Atkinson 312
This page was medically reviewed by Dr Daniel Atkinson on September 04, 2023. Next review due on September 04, 2026.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Mebeverine Mebeverine

How to take Mebeverine

To take mebeverine, follow the instructions below:

  • Take one pill with a glass of water
  • Try to take the pill 20 minutes before a meal
  • Continue to take it until your clinician advises you to stop, even if you feel better.

Dosage

For 135mg tablets:

  • Take one tablet three times a day. This can be lowered as your symptoms improve.

For 200mg MR capsules:

  • Take one capsule twice a day.

What should I do if I make a mistake when taking Mebeverine?

If you accidentally take more than the recommended amount, contact your doctor or emergency department immediately.

If you forget to take a dose, take it as soon as you remember. However, if it’s close to your next dose, skip the missed dose and continue taking it at your usual time. Don’t take a double dose to make up for a missed one.

How long does it take for Mebeverine to work?

Mebeverine is almost instantly absorbed after ingesting and starts to work within one hour. So after 1-3 hours, you should start to feel better.

treated.com This page was written by The Treated Content Team.
Dr Daniel Atkinson 312
This page was medically reviewed by Dr Daniel Atkinson on September 04, 2023. Next review due on September 04, 2026.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Mebeverine Mebeverine

Mebeverine isn’t suitable for everyone, and there are some things that you need to be aware of when using it.

Here’s all the official info on it. If anything is unclear, let our clinician know, and they can talk with you about it.

Mebeverine 135 mg tablets | Mebeverine 200mg modified-release capsules

Mebeverine Mebeverine

FAQ: Mebeverine

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

How effective is Mebeverine for IBS?

Answer:
A meta-analysis of 22 studies on whether mebeverine is an effective treatment for IBS came to the conclusion that Mebeverine was effective at treating a range of IBS symptoms, at a rate of around 25% better than placebo. The studies included a total of 2000 patients each showing IBS symptoms. Some patients received a dosage of mebeverine for varying weeks while others received a placebo. Some of the key findings from the studies were: [1]

  • Abdominal pain and discomfort were found to be improved in 19 of the 22 studies. 

  • The effects of mebeverine on abnormal bowel habits were evaluated in 5 studies (a total of 381 patients). 4 out of the 5 found it to be effective at reducing abnormal bowel habits, while all 5 also reported it had significant improvement in bloating. 

  • Stool consistency also showed improvement in 5 out of 8 studies.

Does Mebeverine cause constipation?

Answer:
Mebeverine is only suitable for people with IBS as a short-term treatment. Although it doesn't have many side effects, individuals with constipation and an inactive gut should consult their clinician before taking it, as it can worsen these conditions.

If you want to treat constipation, it's better to use a laxative like Fybogel or Senna.

How does Mebeverine compare with other treatments for IBS?

Answer:
Mebeverine is the generic version of Colofac. They both contain the same ingredients at the same concentration. The one you choose is completely up to you, both are effective at treating IBS symptoms.

Other similar treatments to Mebeverine include Fybogel Mebeverine. It contains the same active ingredient, mebeverine hydrochloride, and an additional ingredient, ispaghula husk. Together, both ingredients help prevent spasms and regulate bowel movements.

Buscopan is another popular treatment for IBS. It contains hyoscine butylbromide, which works similarly to mebeverine. It stops spasms, which help relieve abdominal pain and discomfort.

To decide which treatment is best for you, answer a few questions about your health and get recommended personalised treatment options.

Can you drink alcohol with Mebeverine?

Answer:
Yes, you can drink alcohol while taking mebeverine. Alcohol does not affect how well mebeverine works, nor does it increase side effects.

Can I take Mebeverine while pregnant or breastfeeding?

Answer:
If you're pregnant, tell your clinician before taking it. Your clinician might prescribe you an alternative option more suitable for pregnant women.

If you’re breastfeeding, Mebeverine should not be taken. Instead, ask your clinician for a safer alternative.

Is Mebeverine available over the counter?

Answer:
Mebeverine 135mg tablets are available as a Pharmacy medicine. This means that you don’t need a prescription for it, but a pharmacist still needs to ask you a few questions to make sure that it’s right for you to take.

Mebeverine 200mg modified-release capsules are only available with a prescription. This is to make sure it's safe and suitable for you to use. If you want Mebeverine, answer a couple of questions online and our clinicians will decide whether it's suitable for you.

Treated trusted sources:

  1. Daniluk, J., Malecka-Wojciesko, E., Skrzydlo-Radomanska, B., & Rydzewska, G. (2022). The Efficacy of Mebeverine in the Treatment of Irritable Bowel Syndrome—A Systematic Review. Journal of Clinical Medicine, 11(4).

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Dr Daniel Atkinson

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Dr-Daniel-Atkinson

Registered with GMC (No. 4624794)

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