- nausea
- pain in the abdomen
- diarrhoea
- headaches.
Taking lymecycline with food can help you feel less sick. For more information on the side effects, check the patient leaflet.
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Last updated on Jul 09, 2026.
Lymecycline is an antibiotic with anti-inflammatory properties that treats perioral dermatitis.
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Lymecycline is an antibiotic. It has anti-inflammatory and antibacterial properties that prevent the growth of bacteria. [1] It’s typically prescribed to treat skin conditions like acne or perioral dermatitis.
Perioral dermatitis is a condition that’s characterised by a red rash around the face. It can be confused with acne as both are red, itchy and have acne-like breakouts. The exact cause is unknown, but the inflammation of the hair follicles and vessels leads to spots commonly around the mouth. [2]It’s normally treated with topical calcineurin inhibitors, or antibiotics if creams don’t work.
Lymecycline is in a category of drugs called tetracyclines. The way drugs in this category work is by binding to the ribosome (the part that makes protein) which stops the production of proteins. The lack of proteins prevents the growth of bacteria, which eventually kills them. It also lowers inflammation by reducing the amount of fatty acids in sebum (the oily substance present on the skin).[3] Excess fatty acids can cause spots, so reducing it can decrease them.

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You should take one capsule with a glass of water, with or without food. It’s preferable to take it in the morning. Depending on the severity of your condition, the dosage might differ.
It’s important to finish the full course of the treatment, even if you think your skin is better. This is to prevent the infection from returning.
Lymecycline is only available in a 408mg capsule. The length of the treatment will depend on the severity of your condition. For Perioral dermatitis, this can be several weeks or even months. Although you should see improvement within a week, it can be a slow and gradual process for your skin to completely clear.

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When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
Lymecycline isn’t suitable for everyone, and there are some things that you need to be aware of when taking it.
Here’s all the official info on it. If anything is unclear, let our clinician know, and they can talk with you about it.
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Last updated on Jul 09, 2026.
Our experts continually monitor new findings in health and medicine, and we update our articles when new info becomes available.
Why this page was updated on Jul 09, 2026
Current version (Jul 09, 2026)
Edited by: The Treated Content Team. Medically reviewed by: Dr Alexandra Cristina Cowell, Writer & Clinical Content ReviewerAug 14, 2023
Published by: The Treated Content Team. Medically reviewed by: Dr Alexandra Cristina Cowell, Writer & Clinical Content ReviewerHow we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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Cristina writes content for Treated, and reviews content produced by our other writers to make sure it’s clinically accurate.
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When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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