Weekly injections to help you lose weight.
Zepbound is a weekly weight loss injection that creates the feeling of fullness, helping to control cravings and limit calorie intake.
It’s expected to be available by March 2024. If you want to be the first to know when we’ve got it, leave your details with us and we’ll notify you.
Zepbound is a weight loss medication that’s similar to Mounjaro. It contains tirzepatide, a drug that makes you feel full and stops you overeating. You don’t have to use treatments to help you lose weight. But if you’ve tried to lose weight in the past by dieting or exercising and it hasn’t worked for you, using Zepbound could make your journey easier and faster.
To get Zepbound, you need to have a BMI of over 30, or over 27 for some ethnic backgrounds, or you have an obesity-related health condition, like high blood pressure. Currently, Zepbound isn’t available on the UK market, but it’s expected to come by March 2024.
Tirzepatide, the active ingredient in Zepbound, is a GLP-1 receptor and a GIP receptor agonist . Tirzepatide binds to and activates both the GIP and GLP-1 receptors. GLP-1 and GIP are two hormones that are found naturally in your body. Their main role is to control your blood sugar levels, but can also control your appetite.
GLP-1 is released from your intestine after eating in two phases. In the first phase, it’s released within minutes and in the second phase after an hour. GLP-1 sends signals to your brain to make you feel full and satiated, preventing overeating. Additionally, it delays the emptying of your stomach, creating the feeling of fullness.
Although previous studies show GIP is linked to promoting obesity, recent studies have found it can induce weight loss. One way it does this is by making you feel full, which leads to a decrease in overall calorie consumption, helping you lose weight.
There are six doses of Zepbound: 2.5mg, 5mg, 7.5mg, 10mg, 12.5mg and 15mg. Your starting dose will be 2.5mg once a week, which may be gradually increased by 2.5mg every four weeks until you’re on the maximum dose of 15mg. Your clinician will put you on a maintenance (long-term) dose of either 5mg, 10mg or 15mg depending on how well you tolerate the treatment.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
Zepbound comes in pre-filled injections with a fixed dose. Each pen will only contain one dose, so can only be used once each time. You’ll use one pen each week, to be taken with or without a meal. It can be taken anytime throughout the day, but try to do it at a similar time each week.
To use the Zepbound pen:
Sometimes you might hear three clicks instead of two, but don’t remove the injection till you hear two loud clicks. A soft click might be heard right after the first one, but this is just the normal operation of the pen. After the injection, you might bleed a little. This is nothing to worry about, just take a cotton ball and place it over the injection site.
Furthermore, you can change the day you take Zepbound as long as there’s a minimum of three days (72 hours) between the two doses. For example, if you currently take Zepbound every Monday at 9 am, feel free to bring your next dose forward to any day after Thursday at 9 am.
Zepbound starts to work as soon as you take the injection. However, it might take a couple of weeks before you start to lose weight and notice a change in your physical appearance. You can make the process happen a little faster, by going on a reduced-calorie diet and exercising more.
It’s best to store Zepbound in a refrigerator between 2°C to 8°C. You can keep your pen at room temperature (30°C) for up to 21 days, but if you’re storing it at room temperature, don’t put it back in the fridge. If your pen is accidentally frozen, don’t use it once it defrosts.
If you pressed the pen before pulling the grey base cap off, discard the pen. Your pen will no longer contain any drug and the needle might be damaged. To avoid this, make sure the pen is in the locked position.
If you accidentally miss a dose of Zepbound, take the dose as soon as you remember (as long as it’s within four days after the missed dose). If more than four days have passed, skip the missed dose and carry on with your normal dosing schedule.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.
Effects of GLP-1 on appetite and weight. Reviews in Endocrine & Metabolic Disorders, 15(3), 181.
Effect of dual glucose-dependent insulinotropic peptide/glucagon-like peptide-1 receptor agonist on weight loss in subjects with obesity. Frontiers in Endocrinology, 14, 1095753.
Glucagon-Like Peptide-1 Receptor Agonists. [Updated 2023 Jan 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan.
Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine, [online] 387(3).
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Meet CraigDelivery, consultation, treatment. It’s all included in the price.
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1 Pen | £249.95 |
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84 Capsules | £56.95 |
168 Capsules | £97.95 Save £15.95 |
252 Capsules | £139.95 Save £30.90 |
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112 Tablets | £143.95 |
224 Tablets | £269.95 Save £17.95 |
336 Tablets | £385.95 Save £45.90 |
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84 Capsules | £61.95 |
168 Capsules | £107.95 Save £15.95 |
252 Capsules | £149.95 Save £35.90 |
Quantity | Starting from |
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1 Pens | £86.95 |
2 Pens | £160.95 Save £12.95 |
3 Pens | £241.95 Save £18.90 |
4 Pens | £287.95 Save £59.85 |
5 Pens | £344.95 Save £89.80 |
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1 Pen(s) | £199.95 |
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1 Pen(s) | £199.95 |
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1 Pen(s) | £199.95 |
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1 Pen(s) | £279.95 |
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1 Pen(s) | £369.95 |
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84 Capsules | £61.95 |
168 Capsules | £112.95 Save £10.95 |
252 Capsules | £158.95 Save £26.90 |
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