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Reviewed on Jan 20, 2026. byDr Alexandra Cristina CowellWriter & Clinical Content ReviewerNext review due on December 24, 2028.
Last updated on Jan 20, 2026.
Product info
Desloratadine is a non-drowsy antihistamine used to treat allergies like hay fever.
It works by blocking histamine, which reduces symptoms like sneezing and itchy eyes.
Can start working within an hour.
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5mg
£36.95
30 Tablets£36.95
60 Tablets£51.95Save £21.95
90 Tablets£66.95Save £43.90
Prices include:
Express shipping
24 hour shipping by secure courier.
Consultation + Access to our clinicians
Ask our experts anything you like, any time you want.
Desloratadine is an antihistamine used to treat allergies including hay fever and eczema.
It’s estimated that between 10% and 30% of the population worldwide have hay fever, so it’s very common.[1] It’s caused by a response to allergens like pollen and pet hair. It produces cold-like symptoms such as a runny nose, itchy eyes and congestion. If it’s caused by pollen, it tends to be worse on windy days, particularly between March and September.
Eczema is a skin condition that causes skin to become dry, flaky and itchy. It can be a very painful condition and is often seen in children. Although it’s not clear what causes eczema, it’s quite commonly found alongside other allergies and produces a similar immune response to that seen in allergies. It’s also made worse by irritants such as soap powder, stress and extreme weather.
How does Desloratadine work?
Antihistamines block the effect of histamines and prevent them from causing the common symptoms of allergies such as hay fever.
Histamine is a natural chemical produced in the body. Its job is to protect your body from allergens. It’s used in cells that come into contact with the environment including those found in the eyes, throat, mouth, lungs and skin.
If your body detects a foreign substance that it sees as being a threat to the body, it triggers specific immune cells to make and release histamine. This is useful and happens without you knowing.
In some cases, the body overreacts to the foreign substance and triggers an extreme response from the body, and too much histamine is produced. This is what causes the symptoms of allergies. The histamines look for ways to clear the body of the allergen. They do this through releasing water from the eyes, mucus from the nose and causing the body to expel the foreign substance through sneezing.
In the case of eczema, the body considers the damaged skin cells to be a foreign substance and a threat to the body. The same response is triggered and histamine is produced to clear the body of the allergen.
What doses of Desloratadine are there?
Desloratadine is available in a 5mg dose tablet. The standard dose is one tablet a day.
If the dose prescribed does not offer relief from your symptoms, speak to your clinician about using an alternative treatment.
This page was written by The Treated Content Team.
This page was medically reviewed by Dr Alexandra Cristina Cowell on December 24, 2025. Next review due on December 24, 2028.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
DesloratadineDesloratadine
How to take Desloratadine
Desloratadine is taken once a day with water. It can be taken with or without food. You can take it anytime of the day, just make sure it’s around the same time every day.
If you are unsure about how to take Desloratadine you should refer to the patient leaflet that comes with your medication. If you can’t find the information that you need, or have any worries about how to take your treatment, get in touch with your clinician.
How long does it take Desloratadine to work?
Desloratadine starts to work within one to three hours and can last all day.[1]
If you find that Desloratadine isn’t working quickly enough, let your clinician know. There may be an alternative treatment that will be more effective for you.
What should I do if I make a mistake when using Desloratadine?
If you forget to take Desloratadine, you should take it as soon as you remember and then continue to take it as you normally would. If it’s almost time for you to take your next dose, skip the dose you missed and carry on as normal.
Never take a double dose of Desloratadine. And if you take too much, seek medical advice straight away.
This page was written by The Treated Content Team.
This page was medically reviewed by Dr Alexandra Cristina Cowell on December 24, 2025. Next review due on December 24, 2028.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
DesloratadineDesloratadine
Desloratadine isn’t suitable for everyone, and there are some things that you need to be aware of when taking it.
Here’s all the official info on it. If anything is unclear, let our clinician know, and they can talk with you about it.
DesloratadineDesloratadine
FAQ: Desloratadine
Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.
How is Desloratadine different from other treatments for allergies?
Answer:
Unlike other antihistamines, Desloratadine is non-drowsy. This means that it can be taken during the day without having an impact on activities such as working and driving.
There are other non-drowsy antihistamines available including Loratadine. Desloratadine is for some people more powerful than Loratadine and so offers more immediate, long-lasting and effective relief from the symptoms of hayfever and eczema.
Is Desloratadine similar to any other treatments?
Answer:
There are other non-drowsy antihistamines available. These include:
Fexofenadine
Cetirizine
Loratadine
Some of these treatments are all available without a prescription and are not as strong as Desloratadine.
Desloratadine is a generic medicine. You may have heard of NeoClarityn, which is a branded version of Desloratadine. Both medicines contain the same ingredients and work in the same way, but the generic version tends to be cheaper.
Which version of Desloratadine should I use?
Answer:
Desloratadine tablets are only available in one dose, so taking them is really simple. You just take one tablet once a day.
Once you start taking Desloratadine you’ll be able to review its effectiveness with our clinician. And if it isn’t working the way that it should, we can explore other treatment options with you.
How effective is Desloratadine?
Answer:
Desloratadine is a very effective antihistamine. Analysis shows that over 80% of people who take it see a significant improvement in the symptoms of hayfever such as runny nose and congestion. [1]
Do I need a prescription for Desloratadine?
Answer:
Yes. You need a prescription for Desloratadine because it’s stronger than other over the counter options you may have taken before.
You also need to be monitored when taking Desloratadine. Your clinician will need to review your symptoms and discuss any side effects that you experience to ensure that it’s the right treatment for you.
Treated trusted sources:
Keith, P.K. and Luciuk, G. (2007).Effectiveness of desloratadine 5 mg once daily in patients with symptoms of seasonal allergic rhinitis: Results of a Canadian multicenter, open-label trial. Clinical Therapeutics, 29(3), pp.419–426.
Last updated on Jan 20, 2026.
How we reviewed this page:
Our experts continually monitor new findings in health and medicine, and we update our articles when new info becomes available.
Why this page was updated on Jan 20, 2026
Content checked and updated as part of our 3-yearly periodic review, to ensure accuracy and currentness.
Current version (Jan 20, 2026)
Edited by: The Treated Content Team.Medically reviewed by: Dr Alexandra Cristina Cowell, Writer & Clinical Content Reviewer
Jan 10, 2023
Published by: The Treated Content Team.Medically reviewed by: Dr Daniel Atkinson, GP Clinical Lead
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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