Sereflo is a combination inhaler that keeps the airways open to help you breathe better and reduce inflammation in the lungs. It’s a preventer inhaler, which means it’ll keep your asthma symptoms at bay to reduce risk of an asthma attack and improve your condition overall.
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Sereflo is a preventer inhaler that uses a combination of two ingredients to help prevent asthma symptoms (like breathlessness and wheezing) by keeping your airways and lungs open. It contains a corticosteroid and a long-acting bronchodilator which work together to reduce your risk of having an asthma attack.
Salmeterol is a bronchodilator, which makes sure your airways are open so air can get in and out easier - this effect can last for up to 12 hours. Fluticasone is the corticosteroid used in Sereflo and it reduces the swelling and inflammation in the lungs. You should use Sereflo every day, even if you don’t have any symptoms. It’s available in two doses and also as a powdered inhaler (Sereflo Ciphaler) which comes in the higher dose of 50/250.
How does it work?
Sereflo works to prevent breathlessness and wheezing, which are symptoms of an asthma attack. Salmeterol and fluticasone are the active ingredients in Sereflo. They work together and perform different jobs as an ongoing treatment for long-term asthma.
Salmeterol is a long-acting bronchodilator. This means it works longer, up to 12 hours, compared to short-acting bronchodilators or reliever inhalers like Salbutamol. Salmeterol targets the lungs directly by keeping the airways open making it easier to breathe.
Fluticasone is a type of corticosteroid called a glucocorticoid, which imitates steroid hormones released by the adrenal glands. It’s an anti-inflammatory medicine that prevents lung cells from releasing chemicals that cause inflammation, swelling and irritation in the lungs. This reduces symptoms of asthma like wheezing and breathing difficulties.
Who is Sereflo for?
Sereflo is for people who suffer from moderate to severe asthma and need a bronchodilator and corticosteroid combined medication to help them manage their condition. If you have moderate asthma but your current inhaler isn’t helping your asthma because of the lower dosage of corticosteroid then Sereflo might be the better option.
Can I get a higher dose of Sereflo?
Sereflo is only available in two doses: 25 micrograms of salmeterol and 125 or 250 micrograms of fluticasone. You’ll usually be prescribed the lowest dose that will manage your asthma first. There are other inhalers that contain the same active ingredients in a lower dosage as well, but your prescriber will assess your asthma before increasing or changing your dose or inhaler.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
SerefloFluticasone + Salmeterol
How to use Sereflo
Use your inhaler every day as instructed by our clinicians. There’s a dose indicator on the inhaler to show the number of doses left. When the indicator shows 40 it’ll turn red, meaning you should order a new one.
Test the inhaler first before using it or if it’s been a while since you last used it. Shake it well and point the mouthpiece away from you. Press the inhaler to release four puffs in the air – the indicator should now show ‘120’. If it’s been a week or more just release two puffs.
To use Sereflo:
Remove the mouthpiece;
Shake the inhaler well;
Breathe out as deep as you can;
Place the mouthpiece in your mouth and breathe in slowly;
As you breathe in, press down to release a puff;
Continue to breathe in;
Hold your breath and remove the inhaler. Hold for a few seconds;
Wait around 30 seconds before your next puff and repeat the steps;
Rinse your mouth out with water or mouthwash or you can brush your teeth. This will help with preventing thrush or your voice from becoming hoarse.
You should take two puffs of Sereflo twice a day - so morning and night (or as your clinician has instructed).
How effective and safe is Sereflo?
Several studies looked atthe safety and effectiveness of the active ingredients used in Sereflo. GOAL (Gaining Optimal Asthma Control) was a 12-month study that looked at patients with chronic asthma, comparing combined salmeterol and fluticasone with just fluticasone as a treatment. It showed that patients who used a combination treatment improved control over their asthma within 16 days versus 37 days on just inhaled corticosteroids.
Another study looking at the safety of corticosteroids showed that a fluticasone and salmeterol treatment resulted in a 21% lower risk of having an asthma attack than a fluticasone-only treatment.
Using a combined therapy like Sereflo is a well-tolerated, cost-effective and effective option to help maintain your asthma symptoms.
Can I use a spacer with Sereflo?
If you’re finding it hard to use the inhaler, our clinicians will recommend a spacer that’s right for you. The Volumatic or AeroChamber Plus are compatible with Sereflo.
It’s important to note that a spacer device is only recommended for the higher dose of Sereflo (25/250). If you’re on the lower dose and you think you need a spacer, tell your prescriber because you might have to change to a different inhaler (with the same ingredients and dose) that can be used with a spacer device.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
SerefloFluticasone + Salmeterol
SerefloFluticasone + Salmeterol
FAQ: Sereflo
Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.
Are there any side effects with Sereflo?
Answer:
All medicines can cause side effects and Sereflo is no different. You might not experience any, however it’s still good to know what to look out for. Headaches can be common, but these should improve as you continue your treatment. Thrush, sore throat or hoarse voice can also affect up to one in ten people. It’s recommended to rinse your mouth out or brush your teeth after using your inhaler to reduce this risk.
If your breathing gets worse after using Sereflo you may be having an allergic reaction so seek urgent medical attention immediately. You also need to use your fast-acting (blue) inhaler. Other reactions to look out for are itching, hives and swelling of the face, lips, tongue or throat. Tell your doctor as soon as possible if you get these – you’ll probably need to switch medication.
Can I use Sereflo if I’m pregnant or breastfeeding?
Answer:
You can use Sereflo whilst pregnant if your clinician has assessed that using the inhaler is of greater benefit than any risk to your baby. You’ll be closely monitored and put on the lowest dose to manage your asthma.
If you are breastfeeding however, you may have to stop breastfeeding or stop using your combined inhaler. This is because there isn’t enough evidence to say the ingredients aren’t excreted into your breastmilk.
Can I use Sereflo for COPD?
Answer:
No. Sereflo hasn’t been tested for safety and efficacy in people with chronic obstructive pulmonary disease and so it can’t be used as a treatment. However there are plenty of treatments available for you if you have COPD, and when you speak to our clinicians they’ll show you a range of medications that are best for you.
Are there any other inhalers that are the same as Sereflo?
Answer:
Other combination inhalers also use the same active ingredients, so may be considered similar. AirFluSal comes as a pressurised inhaler in the same doses (and as a higher dose but in a powdered inhaler). Combisal is similar as it’s also a cheaper alternative like Sereflo compared to other combination inhalers. Seretide and Sirdupla both come in the same doses, and Seretide is also available as Seretide Accuhaler – a powdered inhaler that you may find easier to use.
Do I need a prescription for Sereflo?
Answer:
Yes, Sereflo is a prescription-only medication. This is because it’s not safe for everyone to take, and our prescriber will need to check the condition of your asthma first. They’ll also need to check what dose you need to ensure it’s the right treatment for you.
Why should I buy Sereflo online with Treated?
Answer:
We make getting treatment for asthma easy as we know how it can affect your day to day. We take care of the little details so you don’t have to. Tell us about your health, and we’ll show you the best treatments. All you have to do is choose the medication you want and how often you want it from our pharmacy.
After you’ve received your medication, we’ll stay in touch with you to find out how you’re getting on. That’s aftercare tailored for you. Change, pause or cancel your subscription when it suits you.
Ramamoorthy, Sivapriya, and Cidlowski, John (2016).
"Corticosteroids-Mechanisms of Action in Health and Disease." Rheumatic diseases clinics of North America, vol. 42, no. 1. p. 15. (Accessed 11 Jan 2023).
“Serious Asthma Events with Fluticasone plus Salmeterol versus Fluticasone Alone.” The New England journal of medicine. vol. 374, no. 19. pp. 1822-30. (Accessed 11 Jan 2023).
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