The once-a-day tablet for effective diabetes management.
Rybelsus is a tablet you take once a day to help manage your blood sugar if you have type-2 diabetes. It’s also shown to help people lose weight.
Talk to us about your health and we’ll recommend diabetes treatments that are right for you. When you order Rybelsus online with Treated, you’ll get access to expert aftercare from our clinicians.
Rybelsus is a tablet you take once a day to help control your blood sugar if you have type-2 diabetes. It’s usually prescribed if a first-line treatment like metformin isn’t appropriate, or isn’t enough on its own. The active ingredient in Rybelsus is semaglutide, which increases insulin production after you eat to help manage your blood sugar levels. It can also help you lose weight, by making you feel fuller for longer after eating.
Unlike other treatments that contain semaglutide, which come as weekly injections, Rybelsus is a daily tablet. If you don’t like the idea of taking an injection, but still want a treatment for type-2 diabetes that can help you lose weight, Rybelsus might be a good option for you.
The active ingredient in Rybelsus is a ‘GLP-1 receptor agonist’, called semaglutide. Semaglutide attaches to the receptors of a hormone known as GLP-1 (glucagon-like peptide-1) that’s produced in your gut. It then mimics the action of the GLP-1 hormone, telling your pancreas to increase the amount of insulin it produces after you eat. This helps reduce your blood sugar levels, and keep your diabetes under control.
There are three different Rybelsus doses for the management of type-2 diabetes. The starting dose of Rybelsus is one 3mg tablet once a day, for a month. Your clinician will then increase your dose to one 7mg tablet a day. If a 7mg dose isn’t enough to manage your blood sugar effectively, your clinician may increase your Rybelsus dose to 14mg once a day.
You should only ever take the dose of Rybelsus you’re prescribed. Don’t change your dosage without speaking to your clinician first, and don’t take two 7 mg tablets in place of one 14 mg tablet. This hasn’t been studied and it isn’t known what side effects this could cause.
You should only take Rybelsus as you’re instructed to. If you’re ever unsure how to take Rybelsus, check with your clinician.
You’ll typically start by taking a 3mg tablet once every day for a month. Afterwards, your clinician will increase the dosage to a 7mg tablet once per day. If this isn’t enough to manage your blood sugar effectively, your dose may be increased to a 14mg tablet once a day.
To use Rybelsus:
You may see improvements to your blood sugar levels with Rybelsus after 30 days, but it can take months before significant improvements happen. Studies show that after 26 weeks of taking oral semaglutide, people’s A1C (their average blood sugar level over the last two months) was reduced by 1.2% from the baseline.
If you forget to take your dose of Rybelsus, it’s not an issue. Simply skip the missed dose and take your next dose as normal the following day. If you accidentally take more Rybelsus than you should, speak to your doctor as soon as you can. You may feel or be sick, and require additional monitoring to treat your symptoms.
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Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.
Should metformin remain the first-line therapy for treatment of type 2 diabetes? Therapeutic Advances in Endocrinology and Metabolism. vol. 12. Available at:
Glucagon-like Peptide-1 Receptor Agonists. StatPearls. Treasure Island (FL): StatPearls Publishing. Available at:
Rybelsus: semaglutide. Available at:
(Accessed 23/01/2023)
Package Leaflet: Information for the patient. Rybelsus 3 mg tablets. Rybelsus 7 mg tablets. Rybelsus 14 mg tablets. Semaglutide. Available at:
Oral Semaglutide. Clinical Diabetes. vol. 28, no. 1. pp. 109-111. Available at:
(Accessed 23/01/2023)
Effect of Semaglutide on the Pharmacokinetics of Metformin, Warfarin, Atorvastatin and Digoxin in Healthy Subjects. Clinical Pharmacokinetics. vol. 56, no. 11. pp. 1391-1401. Available at:
The efficacy and safety of liraglutide added to metformin in patients with diabetes: a meta-analysis of randomized controlled trials
Jianqiu Gu, Xin Meng, Yan Guo, Lei Wang, Hongzhi Zheng, Y. Scientific Reports. vol. 6. Available at:
Insights into the early use of oral semaglutide in routine clinical practice: The IGNITE study. Diabetes, Obesity and Metabolism. vol. 23, no. 9. pp. 2177-2182. Available at:
Annex I: Summary of Product Characteristics. Available at:
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