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Reviewed on Apr 25, 2023. by Dr Daniel Atkinson GP Clinical Lead Registered with GMC (No. 4624794) Next review due on April 26, 2026.
Dr Daniel Atkinson

Last updated on Apr 25, 2023.

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  • Esomeprazole is a daily tablet treatment for GORD.

  • It’s a proton pump inhibitor which works by reducing stomach acid.
  • The tablets come in 20mg and 40mg doses.

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  • Prices include:
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Esomeprazole Esomeprazole

What is Esomeprazole?

Esomeprazole is a generic medication that treats symptoms of gastro-oesophageal reflux disease (GORD). It contains the active ingredient esomeprazole magnesium dihydrate, which lowers the levels of stomach acid you produce. This minimises the chance of acid escaping into your gullet, and should reduce any symptoms of acid reflux or heartburn you experience.

How does Esomeprazole work?

Esomeprazole belongs to a type of medications known as proton pump inhibitors (PPIs). PPIs act on proton pump molecules on the cells that secrete gastric acid in your stomach, lowering how much they produce.[1] This reduces the likelihood of acid escaping into your oesophagus and causing symptoms of GORD.

What doses of Esomeprazole are there?

There are two different Esomeprazole dosages available to treat symptoms of GORD: Esomeprazole 20mg and Esomeprazole 40mg. How much Esomeprazole you take will depend on your condition and how well Esomeprazole works to control it.

If your food pipe has been damaged, the usual dose is one 40 mg tablet a day for four weeks, with a possible further four week course if it isn’t fully healed. Once your gullet heals, your clinician will typically reduce your dose to 20mg a day.

If your gullet is undamaged, you’ll typically take up to 20mg of Esomeprazole each day for four to eight weeks, then 20mg daily as needed. If you feel like your GORD isn’t being controlled well enough by your current dose, speak to your clinician. They might increase your dose for a month or two, to see if this helps.

Treated trusted sources:

  1. Kalaitzakis, E. (2007). A review of esomeprazole in the treatment of gastroesophageal reflux disease (GERD). Therapeutics and Clinical Risk Management. 3(4), pp. 653-663.
treated.com This page was written by The Treated Content Team.
Dr Daniel Atkinson 312
This page was medically reviewed by Dr Daniel Atkinson on April 26, 2023. Next review due on April 26, 2026.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Esomeprazole Esomeprazole

How to take Esomeprazole

Always follow your clinician’s instructions when taking Esomeprazole. You can take your tablet at any time of day that suits you, either with or without food. Just try and take it around the same time each day if you’re taking Esomeprazole long-term.

If you struggle with swallowing the tablets, you can dissolve them by stirring your dose into a glass of still water until they break up and dissolve into a cloudy mixture. Drink the mixture within 30 minutes, always making sure it’s well stirred before drinking it. To ensure you’ve had all of the medicine, fill your glass halfway with water and rinse it well, before drinking the remaining mixture.

How long does it take Esomeprazole to work?

You may notice the benefits of Esomeprazole within two or three days of starting your treatment, but it can sometimes take a bit longer to get to work.[1] Studies show that Esomeprazole can control symptoms of heartburn and reflux within four weeks of starting treatment, relieving their frequency and severity.[2]

What should I do if I make a mistake taking Esomeprazole?

You should follow your clinician’s instructions when taking Esomeprazole. If you miss a dose, it’s no big deal. Just take it as soon as you remember. The exception is if it’s almost time for your next dose; in that case, just skip the tablet you missed and take your upcoming dose as normal.

If you take more Esomeprazole than you should, speak to your clinician as soon as you can. You may experience weakness, stomach issues, and other side effects of Esomeprazole.

Treated trusted sources:

  1. NHS, (2022). About esomeprazole.
  2. Jones, R. and Patrikios, T. (2008). The effectiveness of esomeprazole 40 mg in patients with persistent symptoms of gastro-oesophageal reflux disease following treatment with a full dose proton pump inhibitor. International Journal of Clinical Practice. 62(12), pp. 1844-1850.
treated.com This page was written by The Treated Content Team.
Dr Daniel Atkinson 312
This page was medically reviewed by Dr Daniel Atkinson on April 26, 2023. Next review due on April 26, 2026.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Esomeprazole Esomeprazole

Esomeprazole isn’t suitable for everyone, and there are some things that you need to be aware of when taking it.

Here’s all the official info on it. If anything is unclear, let our clinician know, and they can talk with you about it.

Esomeprazole Esomeprazole

FAQ: Esomeprazole

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

Are there any alternatives to Esomeprazole?

Answer:
If Esomeprazole isn’t the right fit for you, there are more GORD treatments available to choose from. If you’re looking for a similar treatment to Esomeprazole, other proton pump inhibitors (like omeprazole, lansoprazole, and pantoprazole) work in the same way.

Can you get side effects from Esomeprazole?

Answer:
Esomeprazole, like all medicines, can cause some side effects – but they won’t affect everyone. The most common side effects of Esomeprazole are:

  • Headache;

  • Stomach pain, diarrhoea, constipation, wind;

  • Nausea and vomiting;

  • Benign stomach polyps.


Using Esomeprazole for a long period of time, especially at a higher dose, can also increase your risk of wrist, spine and hip fractures, as well as low-magnesium levels (hypomagnesaemia). If you have any concerns while taking Esomeprazole, speak to your clinician.

There are some much rarer and more serious side effects of Esomeprazole to watch out for. If you get any of the following side effects, stop taking Esomeprazole and get medical attention immediately:

  • Swelling (in your lips, tongue, and throat or body), a skin rash, fainting, or difficulty swallowing – these could be signs of a severe allergic reaction;

  • Weakness and unexplained bruising (or bruising more easily), which could be a sign of a reduced number of white blood cells or platelets in your blood;

  • Yellowing skin (jaundice), tiredness, and dark urine can be symptoms of liver problems;

  • A severe rash with blistering and peeling that comes on suddenly, even after multiple weeks of treatment.


If you want a more comprehensive guide to the side effects of Esomeprazole, take a look at the patient information leaflet.

Can you use Esomeprazole during pregnancy?

Answer:
If you’re pregnant, think you might be pregnant, or are planning on starting a family – speak to your clinician before taking this medication. They’ll advise you on whether or not you should take Esomeprazole during pregnancy.

We don’t know whether or not Esomeprazole passes into breast milk, so you shouldn’t take it if you’re breastfeeding.

Can you get Esomeprazole over the counter?

Answer:
No. You can’t get generic Esomeprazole over the counter – you’ll need a prescription. However, there is a branded version of Esomeprazole called Nexium Control, which is available over the counter. But you can only get Nexium in lower doses of 10 mg and 20 mg. So if your symptoms are severe, or Nexium isn’t controlling them well enough, generic Esomeprazole could be a better option.

Can you drink alcohol while on Esomeprazole?

Answer:
Alcohol doesn’t affect how Esomeprazole works. In fact, studies show that gastroesophageal reflux was reduced by 93% after Esomeprazole compared with placebo in healthy volunteers.[1]] However, alcohol does make your stomach produce more acid than normal. This can irritate the lining of your stomach, and make the symptoms of GORD worse.[2]

Treated trusted sources:

  1. Franke, A., et al., (2008). Esomeprazole reduces gastroesophageal reflux after beer consumption in healthy volunteers. Scandinavian Journal of Gastroenterology. 43(12), pp. 1425-1431.
  2. NHS, (2022). Common Questions about esomeprazole.

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Dr Daniel Atkinson

GP Clinical Lead
Dr-Daniel-Atkinson

Registered with GMC (No. 4624794)

Meet Daniel  

Ms Sanjeda Chowdhury

Superintendent Pharmacist + Independent Prescriber
Ms-Sanjeda

Registered with GPhC (No. 2202465)

Meet Sanjeda  

Mr Craig Marsh

Independent Prescriber
Mr-Craig

Registered with GPhC (No. 2070724)

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