HRT pill in a neat calendar pack.

Trisequens is a combination hormone replacement therapy medication that is used to treat postmenopausal symptoms like hot flushes and prevent osteoporosis.
Talk to an expert and get tailored treatment recommendations. With Treated, you can order Trisequens online and receive your prescription the next day.
Menopause is caused by low levels of oestrogen and progesterone in women. These low hormone levels cause a variety of symptoms in postmenopausal women including hot flushes, night sweats and an increased risk of osteoporosis. Trisequens is a hormone replacement therapy treatment used to reduce these symptoms.
Trisequens combines estradiol with norethisterone acetate in a hormone replacement therapy treatment with a 28-day cycle. Estradiol is identical to the estrogen that is naturally produced in your body. Norethisterone acetate is a synthetic progestogen that closely mimics the progesterone that is naturally occurring in your body. Together, these hormones work to increase your hormone levels to reduce or eliminate your postmenopausal symptoms.
Trisequens comes in 28-day cycles. It’s a cyclical or sequential HRT product. The oestrogen is dosed continuously (daily) but in two different dosages. The progestogen is only added for 10 days of every 28-day cycle.
The hormones in Trisequens increase the oestrogen and progesterone in your body. This reduces the symptoms associated with menopause. It also reduces the risk of osteoporosis, which can cause brittle bones.
Trisequens is a sequential combined pill for hormone replacement therapy. It is often prescribed for postmenopausal women who have symptoms of the menopause but still have irregular bleeding. It’s not an appropriate treatment for women who have a history of certain cancers, blood clots, heart attack, stroke or liver disease. If you have porphyria or an allergy to any ingredients in Trisequens, you shouldn’t take it.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
Treating menopause symptoms with Trisequens is straightforward. It comes in 28-day pill packs that should be taken in order. Take your pill around the same time each day with a glass of water.
If you miss a dose of Trisequens, take it within 12 hours. If more than 12 hours have gone by, resume your pills the next day. Never take a double dose to make up for a missed dose. If you take more Trisequens than you’re supposed to, contact your doctor for guidance.
Don’t stop taking Trisequens without talking to your doctor first. They will advise you about the effects of discontinuing treatment and discuss other treatment options for you.
Women who take Trisequens often experience reduced postmenopausal symptoms. This sequential hormone replacement therapy treatment is as effective as continuous hormone therapy replacement options .
Trisequens isn’t available in different doses. It contains 2mg of estradiol and 1mg of norethisterone acetate in each pill. Taking your Trisequens at the same time each day maintains your hormones levels to reduce or prevent postmenopausal symptoms.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.
Comparison of continuous and sequential oestrogen-progestogen treatment in women with climacteric symptoms. (1989). Maturitas, 11(1), pp.75–82.
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Menopause (HRT): Here are some other options.
Oestrogen-only HRT patches and pills. For if you've had a hysterectomy, or used with progestins.
Combined continuous HRT patch. Used it's been more than 12 months since your last period.
Sequential dose patch. Use to manage menopause symptoms if you still have periods.
Comes as a continuous or sequential tablet, depending on whether you're still having periods.
Oestrogen-only HRT to tackle vaginal menopause symptoms.
HRT gel you rub into your skin. It has an easy-to-use pump pack for menopause relief.
Oestrogen only tablet or patch for women who've had a hysterectomy, or used alongside a progesterone in combined HRT.
Generic version of Livial. Hormone-free HRT that can improve mood and libido.
The natural progesterone treatment. Taken alongside oestrogen to relieve symptoms of menopause.
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Disclaimer: The information provided on this page is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please talk to a doctor.
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