When does Wegovy peak in the body?

Immediately after injection (Day 0)

After injection, semaglutide is absorbed slowly into your bloodstream.

You won’t feel any effects on this day, as only a small amount may have been absorbed. This usually isn’t enough to produce a noticeable effect.

Day 1

The levels of semaglutide will steadily increase in the bloodstream and travel to the target organ, such as the brain.

You’ll slowly start to feel its effects, like feeling fuller, but this won’t be to its full extent.

Days 2 – 3

Semaglutide reaches peak concentration, with approximately 89% being absorbed. This is the point with the highest level of semaglutide circulating at any given time.

You’ll begin to notice a change in your appetite, often feeling fuller and less hungry.

You may also get side effects like nausea, vomiting, diarrhoea and headaches. Although not everyone gets them, they are completely normal and show that semaglutide is working.

Day 4 – 7

Semaglutide levels will decline slowly until day seven and continue to decrease afterwards.

On day seven, you’ll take another dose to maintain the high levels. As you continue taking weekly doses, a steady state will be achieved by week five , meaning the levels remain consistent until you stop treatment.