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Reviewed on August 02, 2022. by

Dr Daniel Atkinson

GP Clinical Lead

Registered with GMC (No. 4624794)

Next review due on August 01, 2025.

Product info

MUSE comes as a pellet that’sinserted into the penis to create an erection
It typically works within 10-20 minutes and may last for 30-60 minutes.
It’s an option for you if oral ED medications haven’t worked well.

Price checker

Prices include:

Express shipping
24 hour shipping by secure courier.
Consultation + Access to our clinicians
Ask our experts anything you like, any time you want.
Total
£47.95

Save £0.00 each order

MUSE: essential info
MUSE: instructions
Important stuff you need to know
FAQ

How to use MUSE (alprostadil)

Unlike erectile dysfunction pills like Viagra and Cialis, MUSE is administered directly to your penis. The directions below are a guide, but you should always make sure you follow the instructions for MUSE alprostadil in the leaflet.

Clean & prep yourself: Thoroughly wash and dry your hands with a clean towel. Urinate to moisten your urethra, and shake your penis to remove any remaining urine.
Access the applicator: Carefully open the packaging using the easy-open notch. Without grabbing the MUSE applicator, pour it into your hand. Twist the protective cover off of the end of the applicator without touching the stem or tip. Make sure you can see the medicine in the tip of the applicator.
Insert the stem: Pick up the applicator and hold it in a position that is most comfortable for you. In a seated or standing position, gently pull your penis until it reaches its full length. Now you’re ready to slowly insert the stem of the MUSE applicator into your urethra. If you experience any pain or discomfort, pull it out a little before continuing to push it in.
Apply the suppository: There is a button on the end of the applicator. Fully depress the button and hold it for five seconds. Carefully wiggle the applicator from side to side to release the suppository into your urethra—be careful because if you scratch your urethra, you could start bleeding.
Remove the applicator: Pull the applicator out of your penis slowly and carefully. If there’s any medicine remaining in the tip of the applicator, reinsert the stem into your urethra and repeat the directions for applying the suppository.
Distribute the medication: Gently massage the shaft of your penis by rolling it between both hands. Stand or walk around while your erection develops.

How long does MUSE take to work?

After inserting MUSE, you should have an erection within 20 minutes. It should last between thirty minutes to an hour.

Which dose of MUSE is best for me? 250mcg, 500mcg, or 1000mg?

You’ll most likely start out on an alprostadil MUSE dosage of 500mcg to see if your erectile dysfunction is successfully remedied. If you experience side effects like burning, dizziness, or headache, or your erection lasts for longer than an hour, tell your doctor. You may need a lower dose of MUSE alprostadil.

You may also experience an inadequate erection from the starter dose. If this is the case, a doctor may increase your prescription to MUSE alprostadil 1000mcg, or suggest another medicine.

This page was written by The Treated Content Team.

This page was medically reviewed by Dr Daniel Atkinson on August 02, 2022. Next review due on August 01, 2025.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

FAQ: MUSE

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

Why haven’t I heard of MUSE?

Answer:

You may be wondering why you haven’t heard of MUSE. While it is one of the oldest medications for erectile dysfunction treatment, it isn’t the most commonly used. Doctors and patients prefer to try oral medications like Viagra first, and tend to suggest MUSE if other options have failed.

Another reason you might know it as well as other medicines for ED: as treatments go, it’s not quite as convenient as a tablet you simply swallow. It takes a little effort to apply, but it can be helpful for men who can’t use tablets. And it can actually work faster (Viagra can take 30-60 minutes to work, while MUSE can only take 20).

Also unlike other erectile dysfunction medications, MUSE happens to share its name with a popular pop group. As a result, people who search for MUSE often see results for the band instead of the medication.

Is MUSE similar to Caverject or Vitaros?

Answer:

MUSE, Caverject and Vitaros are all alprostadil-based erectile dysfunction medications. They each have a variety of dosages and come in different forms. While MUSE is a urethral suppository, Vitaros is a cream that is inserted into the urethra using an Accudose container. So it’s applied in a very similar way, but the drug is in a different form.

Caverject, on the other hand, comes in the form of an injection delivered into the base of the penis. So this is the same medicine, but is delivered into the body in a different way.

Is MUSE more effective than ED pills?

Answer:

It’s difficult to compare MUSE to a tablet like Viagra, because the scenarios they’re used in are a little different.

In clinical studies, Viagra (sildenafil) has a higher rate of effectiveness in clinical trials, ranging from 63% for the lowest dose and going up to 82% for the highest dose. ^[1] Another study carried out in a UK hospital found that sildenafil had a 91% success rate. ^[2]

A review of MUSE in clinical practice found it was 56% effective. ^[3]

It’s important to remember though that MUSE is generally only used by men who can’t take oral tablets or have tried them and found they haven’t worked. So for these men, MUSE may be much more useful and effective than Viagra, because Viagra isn’t an option for them at all.

Is there another name for MUSE?

Answer:

While there are other alprostadil medications that can treat erectile dysfunction, there aren’t any generic versions of MUSE available at the moment. MUSE is the only urethral suppository available.

How should I store MUSE?

Answer:

Store your unopened MUSE packages in the refrigerator. Once you’ve taken it out of the fridge, you can keep it at room temperature for up to two weeks.

Treated trusted sources:

www.medicines.org.uk. (n.d.). Viagra 100 mg film-coated tablets – Summary of Product Characteristics (SmPC) – (emc). [online]
Sairam, K., Kulinskaya, E., Hanbury, D., Boustead, G. and McNicholas, T. (2002). Oral sildenafil (ViagraTM) in male erectile dysfunction: use, efficacy and safety profile in an unselected cohort presenting to a British district general hospital.. BMC Urology, 2(1).
Guay, A.T., Perez, J.B., Velásquez, E., Newton, R.A. and Jacobson, J.P. (2000). Clinical Experience with Intraurethral Alprostadil (MUSE®) in the Treatment of Men with Erectile Dysfunction. European Urology, 38(6), pp.671–676.