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Reviewed on Aug 29, 2024. by Dr Daniel Atkinson GP Clinical Lead Registered with GMC (No. 4624794) Next review due on Aug 29, 2027.
Daniel

Last updated on May 12, 2022.

What Alprostadil dosages are available

Generic Alprostadil comes in two different dosages: 10mcg and 20mcg vials. These vials are mixed with a solution before the prescribed dose is injected. You’ll typically start on 2.5mcg of Alprostadil and work your way up until you find a dose that works for you.

Finding the right dosage of Alrpostadil can take time, though. The standard dosage tends to be between 5mcg and 20mcg, which is usually effective for the men using it.

Your doctor will slowly increase the dosage to find the right one for you, minimising risks and maximising effectiveness, a process called titration. If you find the medication doesn’t provide you with the results you need without unwanted side effects, a different erectile dysfunction treatment might be suggested.

Alprostadil used to be available under the brand Caverject, but this was discontinued in 2025. Caverject came in 10mcg, 20mcg, and 40mcg vials. A version of Caverject with an easy-to-use syringe that helped mix the medicine for you was also available, called Caverject Impulse Dual Chamber. This only came in 10mcg or 20mcg doses.

While generic Alprostadil isn’t currently available in the 40 mcg dose, it contains the same active ingredient and works in the same way as Caverject – so it’s a good option if you’re looking for Caverject alternatives.

Are Viridal dosages the same as Alprostadil?

Viridal Duo comes in the same doses as Alprostadil (10mcg, 20mcg), as well as a 40mcg dose. It’s essentially the same product as Alprostadil in regards to its active ingredient, it’s just available at a higher dosage. Whilst both products are injected, the injection devices aren’t the same, so the instructions will differ slightly. Viridal Duo comes in an Easy-Duo syringe, which helps mix the active ingredient with a solution for you. If you’re using generic Alprostadil, you’ll need to mix it with this solution in a vial yourself.

If you’re swapping between Alprostadil or Caverject and Viridal, be sure to tell your prescribing clinician so they can make sure you’re comfortable with the new instructions.

Caverject Dual Chamber, Alprostadil Vials & Viridal Duo 10mcg

The lowest dosage product available for alprostadil injections is 10mcg. Alprostadil 10mcg vials, Caverject Dual Chamber and Caverject 10mcg vials are essentially the same product – but the Dual Chamber device was unique to Caverject, whereas the vials are mixed manually before being administered through a needle. You can set the dosage on the device or, when using the vials, it can be measured on the syringe.

The Viridal 10 starter pack uses the EasyDuo device, its instructions differ slightly from the Caverject Dual Chamber or the vials.

At the start of your treatment, it’s likely that your doctor will recommend a dosage of 2.5mcg to 5mcg, whichever the product. The 10mcg dosage is the lowest of the standard products but it’s usually effective enough for most that use it.

If you don’t achieve the results you want from this dosage, and you haven’t experienced any unpleasant side effects, your prescribing clinician might suggest increasing the dosage.

Caverject Dual Chamber, Alprostadil Vials & Viridal Duo 20mcg

Alprostadil 20mcg injections are at the higher end of the standard dosages. As you might expect, they’re more reliable but also present a higher risk of side effects.

This also goes for the Viridal Duo 20mcg continuation pack, although it’s likely you’ll only be prescribed this if you’ve tolerated treatment well. If this dosage is still found to be lacking, it can still be increased to 40mcg.

Caverject Vials & Viridal Duo 40mcg

The 40mcg dose was the highest dosage of Caverject and is the highest dose Viridal Duo. There is no generic Alprostadil 40mcg dosage right now.

It’s unlikely your doctor will prescribe this dosage as a starting point, unless you have previous experience with the medication and it was found that the dosage didn’t cause you any side effects. More often than not, you’ll build up to 40mcg of alprostadil after the lower strength products have been found to be ineffective.

What Vitaros Cream dosages are there?

Vitaros only comes in a 300mcg dose which is available in a 3g tube. It’s generally well tolerated by those that use it but there are occasions where some may experience side effects.

There used to be a lower dose, Vitaros 200mcg (2mg/g), but it’s no longer available as it’s discontinued. 

What MUSE dosages are available?

There are two doses of MUSE: 500mcg and 1000mcg. This allows your prescribing clinician to find the right balance between effectiveness and minimal risk of side effects.

It can take a little time for you to find the best solution, but with some patience and guidance from your doctor, you should be able to access a medication that helps to treat your erectile dysfunction.

MUSE 1000mcg urethral stick

MUSE alprostadil 1000mcg dosages are the highest available for the treatment and are generally only prescribed when the more standard 500mcg dose has not given you the effects you need to achieve and maintain an erection.

It’s possible if you’ve taken MUSE before and found the highest dose best for you that it will be prescribed at the start of treatment, but you’ll need to explain your history of erectile dysfunction and its relevant treatments during your consultation.

MUSE 500mcg urethral stick

MUSE 500mcg is typically the starting dosage to treat erectile dysfunction. Most men will not have any issues with the medication, but should you experience any side effects that concern you, speak with your prescribing clinician.

If you’re not finding MUSE is effective at this strength, then a higher dosage or alternative treatment might be offered.

MUSE 125mcg & 250 mcg urethral stick

In the UK, MUSE 125mcg and 250mcg have been discontinued. They would typically be prescribed if you experienced side effects with the higher doses. The lowest dose now available is MUSE 500mcg. 

If you’re experiencing side effects from MUSE, let your clinician know and they’ll suggest you try a different erectile dysfunction treatment.

When should I change dose if I’m using alprostadil?

The most common reasons for adjusting your dosage of any alprostadil medication are because you’re having issues tolerating it or that it isn’t effective enough. If there’s a lower dosage available, then this is usually a viable option to switch to. It is, however, also possible that you’ll need the dosage altered if medication isn’t effective enough and you haven’t had any significant side effects that would prohibit the dose increasing.

Adjusting the dosage of any medication should be done with the advice and monitoring of a doctor. Do not experiment with your ED treatment without first discussing your options.

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This page was medically reviewed by Dr Daniel Atkinson, GP Clinical Lead on Aug 29, 2024. Next review due on Aug 29, 2027.

Last updated on May 12, 2022.

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