Compare Saxenda with other weight loss treatments

Active ingredient
Available doses
Form
Lasts for
Made/marketed by
Pharmacy status
Prices starting at
Works in
Saxenda

Saxenda

Liraglutide

Highly effective daily injection. It interacts with your brain to make you feel more full.

See treatment  
Liraglutide
6 mg/ml
Injection
Novo Nordisk
Prescription
£86.95
2-3 weeks
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Wegovy

Wegovy

Semaglutide

Weekly injection for weight loss that works by regulating your appetite.

See treatment  
Semaglutide
0.25 mg, 0.5 mg, 1 mg, 1.7 mg, 2.4mg
Injection
Novo Nordisk
Prescription
£199.95
4 weeks
Xenical

Xenical

Orlistat

Branded version of Orlistat. It can help reduce how much fat is absorbed by the body.

See treatment  
Orlistat
120mg
Tablet
Neon Healthcare
Prescription
£61.95
1-3 months
Orlistat

Orlistat

Orlistat

Just like Xenical but without the branding. Can reduce fat absorption by up to 33%.

See treatment  
Orlistat
120mg
Tablet
Multiple
Prescription
£61.95
1-3 months
Mysimba

Mysimba

Buproprion + Naltrexone

A clinically proven weight loss pill. It works on receptors in the brain that control appetite.

See treatment  
Naltrexone/Bupropion
8 mg/90 mg
Tablet
Orexigen
Prescription
£143.95
8 weeks
Alli

Alli

Orlistat

A low dose version of Xenical. It reduces the amount of fat being absorbed by your body.

See treatment  
Orlistat
60mg
Tablet
GlaxoSmithKline
Pharmacy
£56.95
3-6 months
  • Manufacturers subject to change.
  • Start and duration of effects are estimations.
  • For more detailed information on your medication, read the patient information leaflet.

Is weight loss treatment right for me?

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How to choose a weight loss pill

How much we weigh can impact various aspects of our lives. It can hold us back from taking part in certain activities, make us feel unhappy or even impact our mental health. That’s why taking the decision to lose weight is a pretty big one.

Weight loss treatments can be used as part of a healthy weight loss course. However, there are several to choose from and reading up on them may feel overwhelming, especially when you’re looking for the diet pills that actually work.

We’re here to help you get a better understanding of the weight loss medication options available, so you can make the best decision for you.

How do weight loss pills work?

Weight loss pills such as Xenical, Orlistat, and Alli work by effectively creating a barrier that stops fat from being absorbed into your intestines; this fat is passed naturally, which encourages weight loss in the process.

The active ingredients in Mysimba work differently and instead act on the brain. Bupropion works to reduce your appetite and Naltrexone helps to curb food cravings so that you don’t feel the urge to eat as often.

What do diet pills do?

When diet pills are used as part of a healthy diet and exercise programme they can have a positive effect on weight loss. However, it’s not just a case of popping a pill and carrying on regardless, the user will also have to follow a diet plan to help them achieve the best results with the least amount of side effects.

When you decide to embark on a weight loss journey supported by weight loss pills your clinician will outline details of a calorie-controlled diet and a regular exercise plan. Following these instructions will help you achieve your weight loss goals. It’s recommended you speak to your physician before taking part in a high-intensity exercise programme.

Do weight loss pills work?

Licensed medicines like Mysimba and Orlistat have shown to be effective in aiding weight loss, as long as they’re used alongside a calorie controlled diet and exercise. However, how effective different weight loss medications are isn’t always directly comparable, because efficacy isn’t always measured in the same way.

Looking at the data available:

  • Clinical data for Alli found that an average of 46.7 percent of participants lost more than five percent of their weight, compared to 26.4 percent on the placebo, when taking it for six months.
  • For Orlistat, 37 percent of study participants lost at least five percent of their body weight, compared with 19 percent of those taking the placebo, when taking it for 12 weeks.
  • For Mysimba, 31 percent of participants observed a weight loss of five percent or greater, compared to the placebo group at 12 percent, when taking it for 56 weeks.
  • For Saxenda, 63.5 percent of study participants lost at least five percent of their body weight, compared to 26.6 percent in the placebo group, when taking it for 56 weeks.

Efficacy rates are a factor in what treatment you use, but they don’t necessarily decide which is best for you. One particular medicine might be better for you based on how much weight you aim to lose, or your medical history. So it’s always worth getting professional advice.

There is no magical weight loss pill that works overnight, however, if you follow the advice offered by your prescriber, and are determined to stick to your diet and exercise plan, then there are diet pills that work. There are some BMI boundaries that must be adhered to and, as previously mentioned, not all diet pills will work for everyone, but there are slimming pills that work in partnership with a diet and exercise programme to help you lose weight.

Xenical (Orlistat) - pros and cons

Clinical trials have found that following 56 weeks of treatment participants using orlistat were found to have an eight percent weight loss, versus four percent in the placebo group. However, the clinical trials also revealed that some people experience unpleasant side effects, such as fatty stools or flatulence. As Xenical is taken orally it may be favoured by users who aren’t keen on regular injections, like those used by Saxenda and Victoza which have to be regularly injected and first demonstrated by a medical professional.

Alli - pros and cons

One of the advantages of Alli is that it is available without prescription, you will still need to speak to a pharmacist before they can provide you with the treatment, but the simpler access can be viewed as a benefit to some people. Clinical trials have proven that Alli is only marginally effective in comparison to various other weight loss pills as it is given at a lower dose. Both Xenical and Orlistat are administered in larger doses and so are often more effective at reducing weight. Alli might be more suitable for those who wish to lose a smaller amount of weight. Clinical trials have also revealed that taking Alli can result in uncomfortable side effects such as uncontrollable bowel movements, oily discharge, and gas from the anus.

Saxenda - pros and cons

The active ingredient in Saxenda, liraglutide, helped trial participants consistently lose at least five to 10 percent of weight when compared to placebo. It also regulates your hunger and fullness, and stabilises your blood sugar. This can make you feel less cravings and give you better control over your eating habits. However, Saxenda is a prescription injection treatment that requires an initial demonstration by a healthcare professional. Regular injections may be off-putting to some patients. The most common side effects included nausea, diarrhoea, and vomiting.

Litramine/XLS-Medical - pros and cons

Litramine is perhaps viewed as a more gentle weight loss treatment as it can be ingested via tea, sachet, or tablet. Side effects from Litramine are mild if they occur at all. Litramine attaches itself to fat in the body and stops the fat being absorbed by the intestines. Clinical trials found it to absorb as much as 27% of dietary fats. Available without prescription.

Victoza - pros and cons

Victoza is effective at helping people with Type 2 diabetes lose weight, as it can help the body control blood sugar levels, and over a course of 56 weeks has been proven to help lose substantial weight. However, Victoza has to be injected daily, which may not be appealing to everyone, and clinical trials on its effectiveness for non-diabetic overweight people are ongoing. It can be prescribed off-label for weight loss. Victoza can cause users to experience side effects of the digestive system. Its use may be unsuitable for patients with a family history of certain cancers.

Wegovy - pros and cons

Wegovy also boasts the appeal of being a once weekly injection for weight loss. Although, the idea of self administering an injection can put some people off. The clinical trial results for Wegovy show that people lose more weight using semaglutide than when using liraglutide. Most side effects associated with Wegovy are gastrointestinal in nature, although headaches, tiredness and dizziness were also recorded. In most cases the side effects settled down quickly and didn’t stop patients from continuing with their treatment.

Mysimba - pros and cons

Mysimba will usually make you eat less food, which can cut out overeating habits and reduce your appetite. It’s also very effective. In a trial involving 1742 people, the Mysimba group lost 6.1% of their body fat, compared with 1.3% of the placebo group. There is, however, a higher risk of side effects than there is with some other weight loss treatments, and you’ll need a prescription for it before you can buy and take it.

Are there any diet pills that work fast without exercise?

We’re afraid not. There are no magical solutions to losing weight. Weight loss medication can be used alongside a balanced diet and healthy exercise routine to help boost your weight loss goals. Adopting regular exercise into your routine should be viewed as an added positive, as it will help you with your weight loss journey but also provide other health benefits too. Exercise not only helps your physical health but your mental health too.

What is the best prescription diet pill on the market?

The best prescription diet pill for you is the one that fits with your lifestyle and your goals. Important aspects you need to take into consideration are side effects, administration and prescription. What is a good prescription weight loss pill for one person may be different to another person.

A medication that works and doesn’t cause uncomfortable side effects that allows you to enjoy a healthy lifestyle alongside it is a good prescription weight loss pill.

What are the best over-the-counter weight loss pills?

Alli and XLS are the only weight loss pills available without prescription, however, it’s always recommended you speak to a professional before commencing a weight loss programme of any kind. Alli has some uncomfortable side effects and in clinical trials offers minimal assistance when losing weight. XLS is a naturally based weight loss pill, has mild side effects, can absorb as much as 27% dietary fats but again might only help you shift a few extra pounds versus dieting and exercising alone.

How to safely use weight loss medication

Choosing to start a weight loss journey may seem daunting at first. Having all the information you need can make all the difference. Read more about weight loss medication and make sure you’re on the right path from start to finish so that you can safely achieve your goals.

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This page was medically reviewed by Dr Daniel Atkinson, GP Clinical Lead on August 02, 2022. Next review due on August 02, 2024.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

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Treated

Here's how we're doing so far.

551

Excellent

551

Shipping is speedy and the product is amazing.

551

All good.

551

Really helped me

551

Trusted service and great service - next day delivery and I can rely on them to send regularly.

551

Ordering was straight forward, tablets delivered promptly and well packaged, and instructions were clear, thanks.

4.8

Our average rating based on 3543 reviews.

551

100% recomended.Great service

551

Excellent service

551

Excellent delivery. Can’t fault.

551

Quick and efficient service, delivered discreetly the next day. Thank you.

551

Effective

551

Great service, no wait time

551

Great

551

Quick assessing for medicine suitability. Quick delivery and good communication throughout.

551

Straightforward and quick service!

551

Good however communication could sometimes be better

551

Easy and good procedure to get treatment

551

Excellent product

551

Excellent service!!! Ordered what I needed sent a picture of my prescription and the parcel arrived the next day!!! Will definitely order again and have recommended to others!!!

551

Fast shipping

551

Very quick service all round

551

So quick and simple. Recommend

551

Great

551

Very convenient hassle free service.

551

Easy to use good communication and fast shipping

551

Great service

551

Efficient no issues re delivery

551

Fabulous service

551

Brilliant service. Not a bad word to say!

551

It was fast, professional and it's the right med for what I selected in there.

551

This review requires content. Oh well..

551

Great service, quite effortless.

551

Top notch

551

Brill service

551

N/a

551

Excellent service quick and easy to use

551

Fast and exact order

551

Superb service and quick delivery 10/10

551

Excellent service

551

Thank you for fast delivery

551

Shipping is extremely quick and satisfiying

551

Good stuff

551

Good service

551

Great fast delivery

551

Very good service well packaged

551

Speedy delivery great service

551

The shipping was great n received on time

551

Excellent service.

551

Excellent service

551

Had to rearrange my delivery DPD were excellent

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