FemSeven

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Reviewed on Feb 26, 2026. by Dr Alexandra Cristina Cowell Writer & Clinical Content Reviewer Next review due on February 25, 2029.

Last updated on Feb 26, 2026.

Product info

FemSeven is an oestrogen-only skin patch for menopausal women.
Unlike other HRT treatments, it contains a single hormone.
The patches are applied directly to your skin to alleviate symptoms.

Price checker

Prices include:

Express shipping
24 hour shipping by secure courier.
Consultation + Access to our clinicians
Ask our experts anything you like, any time you want.
Total
£37.95

Save £0.00 each order

FemSeven: essential info
FemSeven: instructions
Important stuff you need to know
FAQ

What is FemSeven?

Femseven is a patch you stick to your skin to alleviate the symptoms of the menopause. It’s also known as FemSeven Mono, as it only contains one active ingredient, estradiol hemihydrate. This is a form of the hormone oestrogen. Other HRT treatments can also contain a type of medication known as a progestin, a man-made version of the hormone progesterone. These are known as combined HRT.

Who is FemSeven for?

FemSeven patches are for postmenopausal women who haven’t had a period in over 12 months.^[1] If you’re just starting to experience symptoms of perimenopause and still having irregular periods (also known as the menopausal transition) you’ll be prescribed a different treatment (like Evorel Sequi).

Oestrogen-only HRT treatments like FemSeven are best suited to women who have had their uterus removed (a hysterectomy). This is because taking oestrogens alone over a long period of time can increase the risk of developing endometrial hyperplasia (thickening of the womb’s lining) and endometrial cancer (cancer of the womb’s lining). If you haven’t had a hysterectomy, a treatment that also contains a progesterone will be prescribed instead. Progesterone counteracts and balance the effects of oestrogen in the body, reducing the heightened risk of cancer^[2]

How does FemSeven work?

The menopausal transition is when the levels of oestrogen and progesterone produced by women’s ovaries go down as they get older. The decrease in hormones can cause symptoms like low mood, anxiety, hot flushes, sleeplessness, and vaginal pain or dryness.^[3]

FemSeven patches are applied directly to the skin, allowing your body to absorb oestrogen from them. This balances your body’s oestrogen levels, and helps treat the symptoms of menopause. While it won’t ‘cure’ the menopause, it should make your symptoms much more manageable (or even stop them entirely).

What doses do FemSeven patches come in?

There are three doses of FemSeven patches, and you’ll be prescribed the lowest dose for as little time as necessary in order to treat your symptoms^[1] This is to minimise the risk of side effects. If you feel your dose is too high or too low for your current symptoms, speak to your clinician. They’ll work with you to find the dosage that works best for you.

The lowest dose of FemSeven patch available is FemSeven 50, where each patch contains 1.5 milligrams of estradiol, releasing a 50 microgram dose every day. If this is too low to treat your symptoms, your doctor may suggest moving to FemSeven 75 patches. These contain 2.25mg of estradiol, and release 75mcg per 24-hours. The highest dose of FemSeven patches available are Femseven 100, which each contain 3mg of estradiol, and release 100mcg per day.

Treated trusted sources:

Electronic Medicines Compendium (2021) Package Leaflet: Information for the User: FemSeven® 75, 75 micrograms/24 hours, transdermal patch.
Yang S, Thiel KW, Leslie KK, (2011) ‘Progesterone: the ultimate endometrial tumor suppressor.’ Trends Endocrinol Metab. Vol. 22, no. 4. pp. 145-152.
’What is Menopause?’ ‘National Institute on Aging.

This page was written by The Treated Content Team.

This page was medically reviewed by Dr Alexandra Cristina Cowell on February 25, 2026. Next review due on February 25, 2029.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

How to use FemSeven Patches

FemSeven patches are applied to the skin once a week. You’ll wear your patch for seven days and then swap it for a fresh one on the next day, so you’re always wearing a patch. If it’s the first time you’re using a FemSeven patch, you can usually start your treatment on any day that suits you.

To use your FemSeven patch:

open the pouch by tearing the perforated edges, and remove your patch.
using the S-shaped split, peel off half of the protective liner covering your patch to reveal the adhesive surface underneath. Make sure not to touch this before you stick it to your skin, as this can stop it adhering properly later.
apply the patch somewhere that your skin isn’t wrinkled, and where it’s less likely to be rubbed off by clothing. Good places to choose are the buttocks, hips, or abdomen. Never apply a patch on or around your breasts. Make sure the area you pick is clean, dry, and not broken or irritated.
peel away the second half of the protective liner, and press the patch firmly against your skin with the palm of your hand for 30 seconds. Your body’s warmth will help the patch to stick better.

All you need to do to remove a patch is lift one edge away from your skin and pull. Make sure to fold it in half so the adhesive sticks to itself, then throw it away. You should never apply a new patch to the same place you just removed one from.

How long does it take for FemSeven to work?

After starting your menopause treatment with FemSeven, it might take a few weeks before you feel the full benefit. Typically, you’ll use your treatment for around three months before having a chat with your clinician. If it’s helping with your symptoms, you’ll likely continue with the therapy while seeing them for regular check ups. This is to make sure it’s still a safe and suitable treatment for you. And if it isn’t, they might change your dose, or the type of HRT you’re using.

What should I do if my FemSeven patches aren’t sticking?

If you’re having trouble with your FemSeven patches not sticking, there are a couple of things you can try. Make sure the spot you’re applying the patch to isn’t oily, irritated, dry or broken. This will give the patch a good surface to adhere to. Then, make sure to press down firmly on the patch for at least 30 seconds. The heat from your body and hand will make the patch stick better. You can also try and press down on the patch for up to 30 seconds in the morning or throughout the day to ensure it stays down.

If you still find your patches are coming off, you can try using a transparent film to hold them in place.

If your patch starts to peel off before the seven days are up, remove it completely and apply a fresh patch. You should replace this new patch when you would have replaced the old one.

What should I do if I make a mistake using FemSeven patches?

You should only ever use your FemSeven patches as you’re instructed to by your clinician. If you forget to change your patch on your usual day, apply a new one as soon as you remember. Then continue to change your patch on your original, normal change day (even if that means you wear the new patch for less than seven days).

If you accidentally apply more patches than you should, remove all the patches you currently have on. You shouldn’t need any treatment, but you could experience some menstruation-like bleeding. If you have any concerns, get in touch with your doctor or clinician.

Treated trusted sources:

This page was written by The Treated Content Team.

This page was medically reviewed by Dr Alexandra Cristina Cowell on February 25, 2026. Next review due on February 25, 2029.

How we source info.

FAQ: FemSeven

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

Can FemSeven patches cause side effects?

Answer:

There’s a chance that while taking FemSeven you’ll experience side effects, but not everyone will. The most common of these include vaginal bleeds, fluid retention, breast tenderness, headaches and mood changes.^[1] After you’ve been using HRT for about three months, these side effects should pass.

The more serious adverse effects linked to HRT therapy are an increased risk of certain cancers. Oestrogen-only treatments like FemSeven have been linked with increased risks of endometrial cancer, and combined HRT medications have been reported to heighten the risk of breast cancer.^[2]

If you’ve had a hysterectomy, you typically don’t need to worry about the risk of endometrial cancer. The exception to this is if you’re currently or have previously suffered from endometriosis. This is where tissue similar to the lining of the womb grows elsewhere in the body. If this is the case, you may still be at risk of endometrial cancer in any tissues elsewhere in your body, and a combined treatment will be more appropriate for you.

While there is a link between combined HRT and an increased risk of breast cancer, this risk might be lower for younger women. It’s thought that there is a window of time during the menopausal transition, close to the menopause, where the benefits of HRT treatment far outweigh any risks.^[2] In women over the age of 60, this may not be the case.

Other serious risks linked to HRT are blood clots, for which the risk is 1.3 to 3 times higher for HRT users compared to non-users, and stroke, the risk being 1.5 higher in HRT users.^[1]

Do FemSeven patches cause weight gain?

Answer:

Some women have reported gaining weight while using HRT. Despite this, there is currently no scientific evidence linking HRT with any significant weight gain.^[1]

How effective is FemSeven?

Answer:

In a study in which 142 postmenopausal women were given either FemSeven or Systen, both treatments improved symptoms of hot flushes, insomnia, headaches, vaginal dryness, loss of libido and more. While both groups showed an increased health-related quality of life, the size of this increase in those taking FemSeven was greater than Systen. ^[3]

What are alternatives to FemSeven?

Answer:

Depending on the type of HRT you need, there are plenty of options available to choose from. If you still have your uterus and need combined HRT, FemSeven Conti patches contain the progestin levonorgestrel alongside estradiol. This will reduce any increased risk of endometrial cancer from taking estradiol.

If you’re getting irregular periods, FemSeven Sequi is a sequential version of combined HRT. Sequential HRT is where you take oestrogen-only HRT continuously, and for the last fortnight of your monthly cycle take a progestin alongside it. This should result in you having a menstrual bleed towards the end of each month.

Can you use FemSeven patches when you’re pregnant?

Answer:

As it’s only intended for postmenopausal women, FemSeven is not appropriate for pregnant women to use. If you become pregnant while using FemSeven, stop using it right away and get in touch with your doctor.

Is FemSeven Prescription only?

Answer:

Yes; you’ll need a prescription in order to use FemSeven patches. This is to ensure it’s safe for you to use. Get in touch with our experts, and they’ll let you know which HRT treatments are most appropriate for you.

Treated trusted sources:

Harper-Harrison G, Shanahan MM (2022) ‘Hormone Replacement Therapy.’ StatPearls.Treasure Island (FL): Statpearls Publishing.
Cagnacci A, Venier M (2019) ‘The Controversial History of Hormone Replacement Therapy’ Medicina (Kaunas) vol. 55, no. 9. p. 602
Gambacciani M, Grossi E (1999) ‘Impact of Transdermal Estrogens Treatment on Post-menopausal Symptoms and Health-related Quality of life: an itlian Multicentre Trial.’ Menopause. vol. 6, no. 4. p. 361